A contribution of mouse dendritic cell-derived IL-2 for NK cell activation

Francesca Granucci, Ivan Zanoni, Norman Pavelka, Serani L H Van Dommelen, Christopher E. Andoniou, Filippo Belardelli, Mariapia A. Degli Esposti, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNγ, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalJournal of Experimental Medicine
Volume200
Issue number3
DOIs
Publication statusPublished - Aug 2 2004

Keywords

  • Dendritic cells
  • Innate immune response
  • Interferon γ
  • Interleukin 2
  • NK cells

ASJC Scopus subject areas

  • Immunology

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    Granucci, F., Zanoni, I., Pavelka, N., Van Dommelen, S. L. H., Andoniou, C. E., Belardelli, F., Degli Esposti, M. A., & Ricciardi-Castagnoli, P. (2004). A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. Journal of Experimental Medicine, 200(3), 287-295. https://doi.org/10.1084/jem.20040370