A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound14C-serotonin release in patients with previous myocardial infarction

M. Cortellaro, C. Boschetti, G. Fassio, M. Basagni, E. E. Polli

Research output: Contribution to journalArticle

Abstract

Preliminary data obtained in the ambit of Anturan Reinfarction Italian Study (ARIS) show that, in postmyocardial infarction, reduced platelet survival time occurred in hyperbetalipoproteinemic palients treated with placebo, but not in the group of patients treated with sulfinpyrazone (interaction between treatment and lipemic level is at p ~ 0.1). The sulfinpyrazone effect on platelet survival is probably related to the release reaction inhibition as suggested by our ex vivo results on platelet-bound 14C-serotonin release.

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalActa Haematologica
Volume61
Issue number2
DOIs
Publication statusPublished - 1979

Keywords

  • Hyperbetalipoproteinemia
  • Myocardial infarction
  • Platelet serotonin release
  • Platelet survival
  • Sulfinpyrazone

ASJC Scopus subject areas

  • Hematology

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