A controlled study of the suppression of tinnitus by lidocaine infusion

(Relationship of therapeutic effect with serum lidocaine levels)

E. Perucca, P. Jackson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug. Experiments were conducted under controlled conditions in that neither the attending physician nor the patient was aware of whether active drug or placebo was being infused at any particular time. A significant relationship between serum level and effect was observed in two patients. In the remaining patients this relationship was not readily apparent but there was still a trend for a better response to be seen at higher levels. A satisfactory response was generally seen at levels above 1 μg/ml. The results are consistent with the hypothesis that the transient nature of the symptomatic relief caused by lidocaine is related to the fast clearance of the drug from the body.

Original languageEnglish
Pages (from-to)657-661
Number of pages5
JournalJournal of Laryngology and Otology
Volume99
Issue number7
Publication statusPublished - 1985

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Tinnitus
Therapeutic Uses
Lidocaine
Serum
Pharmaceutical Preparations
Intravenous Infusions
Placebos
Physicians

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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abstract = "The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug. Experiments were conducted under controlled conditions in that neither the attending physician nor the patient was aware of whether active drug or placebo was being infused at any particular time. A significant relationship between serum level and effect was observed in two patients. In the remaining patients this relationship was not readily apparent but there was still a trend for a better response to be seen at higher levels. A satisfactory response was generally seen at levels above 1 μg/ml. The results are consistent with the hypothesis that the transient nature of the symptomatic relief caused by lidocaine is related to the fast clearance of the drug from the body.",
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AB - The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug. Experiments were conducted under controlled conditions in that neither the attending physician nor the patient was aware of whether active drug or placebo was being infused at any particular time. A significant relationship between serum level and effect was observed in two patients. In the remaining patients this relationship was not readily apparent but there was still a trend for a better response to be seen at higher levels. A satisfactory response was generally seen at levels above 1 μg/ml. The results are consistent with the hypothesis that the transient nature of the symptomatic relief caused by lidocaine is related to the fast clearance of the drug from the body.

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