Abstract
Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa.
| Original language | English |
|---|---|
| Article number | 17 |
| Journal | Molecular Cancer |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 31 2018 |
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Keywords
- Adjacent mucosa
- Localized colon cancer
- MicroRNAs
- Predictive markers
- Relapse
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Cancer Research
Cite this
A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer. / Grassi, Angela; Perilli, Lisa; Albertoni, Laura; Tessarollo, Sofia; Mescoli, Claudia; Urso, Emanuele D.L.; Fassan, Matteo; Rugge, Massimo; Zanovello, Paola.
In: Molecular Cancer, Vol. 17, No. 1, 17, 31.01.2018.Research output: Contribution to journal › Letter
}
TY - JOUR
T1 - A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer
AU - Grassi, Angela
AU - Perilli, Lisa
AU - Albertoni, Laura
AU - Tessarollo, Sofia
AU - Mescoli, Claudia
AU - Urso, Emanuele D.L.
AU - Fassan, Matteo
AU - Rugge, Massimo
AU - Zanovello, Paola
PY - 2018/1/31
Y1 - 2018/1/31
N2 - Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa.
AB - Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa.
KW - Adjacent mucosa
KW - Localized colon cancer
KW - MicroRNAs
KW - Predictive markers
KW - Relapse
UR - http://www.scopus.com/inward/record.url?scp=85041480572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041480572&partnerID=8YFLogxK
U2 - 10.1186/s12943-018-0770-8
DO - 10.1186/s12943-018-0770-8
M3 - Letter
C2 - 29386021
AN - SCOPUS:85041480572
VL - 17
JO - Molecular Cancer
JF - Molecular Cancer
SN - 1476-4598
IS - 1
M1 - 17
ER -