Abstract
Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa.
Original language | English |
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Article number | 17 |
Journal | Molecular Cancer |
Volume | 17 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 31 2018 |
Keywords
- Adjacent mucosa
- Localized colon cancer
- MicroRNAs
- Predictive markers
- Relapse
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Cancer Research