A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci

Mauro Boiocchi, Riccardo Dolcetti, Roberta Maestro, Giordana Feriotto, Silvana Rizzo, Valli De Re, Fulvia Sonego

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Abstract

Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near amyc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene expression pattern. Of the six lymphomas analyzed, three showed the MCF 247 provirus integrated within the N-myc locus, one carried the provirus integrated near c-myc, whereas for the remaining two, no evidence of proviral integrations in any of the knownmyc loci was obtained. Independently of the integrative events, the pattern of proto-oncogene expression was almost identical in all six lymphomas. These findings seem to rule out the existence of a peculiar pathway of transformation associated with the proviral insertion near amyc locus. Moreover, the transcription pattern observed was qualitatively identical to that displayed by normal thymocytes; only quantitative differences in c- or N-myc, c-myb and Ha-ras were observed. These results suggest that the T-cell proto-oncogene activation program is not qualitatively affected by the transforming event(s).

Original languageEnglish
JournalLeukemia Research
Volume14
Issue number6
DOIs
Publication statusPublished - 1990

Keywords

  • lymphoma
  • Proto-oncogene
  • proviral insertion
  • retrovirus
  • T-cell

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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