Abstract
OBJECTIVE We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P0.05). CONCLUSIONS Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1587-1594 |
| Number of pages | 8 |
| Journal | Prostate |
| Volume | 71 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Oct 1 2011 |
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Keywords
- lymph node excision
- neoplasms/pathology
- prostatic neoplasms/surgery
ASJC Scopus subject areas
- Urology
- Oncology
- Medicine(all)
Cite this
A critical assessment of the value of lymph node dissection at radical prostatectomy : A population-based study. / Abdollah, Firas; Schmitges, Jan; Sun, Maxine; Tian, Zhe; Briganti, Alberto; Shariat, Shahrokh F.; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I.
In: Prostate, Vol. 71, No. 14, 01.10.2011, p. 1587-1594.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A critical assessment of the value of lymph node dissection at radical prostatectomy
T2 - A population-based study
AU - Abdollah, Firas
AU - Schmitges, Jan
AU - Sun, Maxine
AU - Tian, Zhe
AU - Briganti, Alberto
AU - Shariat, Shahrokh F.
AU - Perrotte, Paul
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I.
PY - 2011/10/1
Y1 - 2011/10/1
N2 - OBJECTIVE We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P0.05). CONCLUSIONS Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients.
AB - OBJECTIVE We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P0.05). CONCLUSIONS Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients.
KW - lymph node excision
KW - neoplasms/pathology
KW - prostatic neoplasms/surgery
UR - http://www.scopus.com/inward/record.url?scp=80052084668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052084668&partnerID=8YFLogxK
U2 - 10.1002/pros.21376
DO - 10.1002/pros.21376
M3 - Article
C2 - 21480307
AN - SCOPUS:80052084668
VL - 71
SP - 1587
EP - 1594
JO - Prostate
JF - Prostate
SN - 0270-4137
IS - 14
ER -