A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study

Firas Abdollah, Jan Schmitges, Maxine Sun, Zhe Tian, Alberto Briganti, Shahrokh F. Shariat, Paul Perrotte, Francesco Montorsi, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

OBJECTIVE We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P0.05). CONCLUSIONS Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients.

Original languageEnglish
Pages (from-to)1587-1594
Number of pages8
JournalProstate
Volume71
Issue number14
DOIs
Publication statusPublished - Oct 1 2011

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Prostatectomy
Lymph Node Excision
Prostatic Neoplasms
Population
Mortality
Survival
Cost-Benefit Analysis
Neoplasms
Survival Rate
Lymph Nodes
Regression Analysis

Keywords

  • lymph node excision
  • neoplasms/pathology
  • prostatic neoplasms/surgery

ASJC Scopus subject areas

  • Urology
  • Oncology
  • Medicine(all)

Cite this

Abdollah, F., Schmitges, J., Sun, M., Tian, Z., Briganti, A., Shariat, S. F., ... Karakiewicz, P. I. (2011). A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study. Prostate, 71(14), 1587-1594. https://doi.org/10.1002/pros.21376

A critical assessment of the value of lymph node dissection at radical prostatectomy : A population-based study. / Abdollah, Firas; Schmitges, Jan; Sun, Maxine; Tian, Zhe; Briganti, Alberto; Shariat, Shahrokh F.; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I.

In: Prostate, Vol. 71, No. 14, 01.10.2011, p. 1587-1594.

Research output: Contribution to journalArticle

Abdollah, F, Schmitges, J, Sun, M, Tian, Z, Briganti, A, Shariat, SF, Perrotte, P, Montorsi, F & Karakiewicz, PI 2011, 'A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study', Prostate, vol. 71, no. 14, pp. 1587-1594. https://doi.org/10.1002/pros.21376
Abdollah, Firas ; Schmitges, Jan ; Sun, Maxine ; Tian, Zhe ; Briganti, Alberto ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I. / A critical assessment of the value of lymph node dissection at radical prostatectomy : A population-based study. In: Prostate. 2011 ; Vol. 71, No. 14. pp. 1587-1594.
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AB - OBJECTIVE We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P0.05). CONCLUSIONS Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients.

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