A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Adele Ferro, Roberto Roiz-Santiáñez, Victor Ortíz-García de la Foz, Diana Tordesillas-Gutiérrez, Rosa Ayesa-Arriola, Noemi de La Fuente-González, Lourdes Fañanás, Paolo Brambilla, Benedicto Crespo-Facorro

Research output: Contribution to journalArticlepeer-review

Abstract

The post-central gyrus (PoCG) has received little attention in brain imaging literature. However, some magnetic resonance imaging (MRI) studies have detected the presence of PoCG abnormalities in patients with schizophrenia. Fifty-six first-episode schizophrenia patients, selected through the program of first-episode psychosis (PAFIP) and carefully assessed for dimensional psychopathology and cognitive functioning, and 56 matched healthy controls were scanned twice over 1-year follow-up. PoCG gray matter volumes were measured at both time-points and compared between the groups. Differences in volume change over time and the relationship between PoCG volume and clinical and cognitive variables were also investigated. The right PoCG volume was significantly smaller in patients than in controls at the 1-year follow-up; furthermore, it was significantly smaller in male patients compared with male controls, with no differences in female. Although there was no significant time by group interaction in the overall sample, a trend-level interaction was found for the right PoCG in males. This is the first study, as per our knowledge, to focus on PoCG in first-episode schizophrenia patients. The presence of PoCG abnormalities in the first year of schizophrenia suggests a possible contribution to the pathophysiology of the illness, probably as part of a more extensive network of abnormalities.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume231
Issue number1
DOIs
Publication statusPublished - Jan 30 2015

Keywords

  • BRAINS2
  • Cognition
  • Follow-up
  • MRI
  • Parietal
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)
  • Medicine(all)

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