A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer

Ola Magne Vagnildhaug, Trude Rakel Balstad, Sigrun Saur Almberg, Cinzia Brunelli, Anne Kari Knudsen, Stein Kaasa, Morten Thronæs, Barry Laird, Tora Skeidsvoll Solheim

Research output: Contribution to journalArticle

Abstract

PURPOSE: The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the consensus definition for cancer cachexia in 2011, there is now a need to establish estimates of prevalence. Therefore, the primary aim of the present study was to assess the prevalence of cachexia in an unselected cancer population. A secondary aim was to assess patient-perceived need of attention to cachexia.

METHODS: A cross-sectional study in hospital patients was undertaken. Key inclusion criteria were the following: age > 18 years, cancer diagnosis, and no surgery the preceding 24 h. Data on demographics, disease, performance status, symptoms, cachexia, and patients' perceived need of attention to weight loss and nutrition were registered.

RESULTS: Data were available on 386 of 426 eligible patients. Median age (IQR) was 65 years (56-72), 214 (55%) were male and 302 (78%) had a performance status of 0-1 (Eastern Cooperative Oncology Group). Prevalence of cachexia (inpatients/outpatients) was 51/22%. Prevalence was highest in patients with gastrointestinal cancer (62/42%) and lung cancer (83/36%). There was no major difference in prevalence between patients with metastatic (55/24%) and localized disease (47/19%). Twenty percent of inpatients and 15% of outpatients wanted more attention to weight loss and nutrition. Cachexia (p < 0.001), symptoms of mood disorder (p < 0.001), and male gender (p < 0.01) were independently associated with increased need of attention.

CONCLUSION: Cachexia is a prevalent condition, affecting both patients with localized and metastatic cancer. Clinical attention to the condition is a sizeable unmet need.

Original languageEnglish
Pages (from-to)1871-1880
Number of pages10
JournalSupportive Care in Cancer
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Cachexia
Cross-Sectional Studies
Neoplasms
Weight Loss
Inpatients
Outpatients
Gastrointestinal Neoplasms
Mood Disorders
Semantics
Uncertainty
Lung Neoplasms
Demography

Cite this

Vagnildhaug, O. M., Balstad, T. R., Almberg, S. S., Brunelli, C., Knudsen, A. K., Kaasa, S., ... Solheim, T. S. (2018). A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer. Supportive Care in Cancer, 26(6), 1871-1880. https://doi.org/10.1007/s00520-017-4022-z

A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer. / Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Almberg, Sigrun Saur; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Thronæs, Morten; Laird, Barry; Solheim, Tora Skeidsvoll.

In: Supportive Care in Cancer, Vol. 26, No. 6, 06.2018, p. 1871-1880.

Research output: Contribution to journalArticle

Vagnildhaug, OM, Balstad, TR, Almberg, SS, Brunelli, C, Knudsen, AK, Kaasa, S, Thronæs, M, Laird, B & Solheim, TS 2018, 'A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer', Supportive Care in Cancer, vol. 26, no. 6, pp. 1871-1880. https://doi.org/10.1007/s00520-017-4022-z
Vagnildhaug, Ola Magne ; Balstad, Trude Rakel ; Almberg, Sigrun Saur ; Brunelli, Cinzia ; Knudsen, Anne Kari ; Kaasa, Stein ; Thronæs, Morten ; Laird, Barry ; Solheim, Tora Skeidsvoll. / A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer. In: Supportive Care in Cancer. 2018 ; Vol. 26, No. 6. pp. 1871-1880.
@article{574674548888403791a182aa6e8d0e06,
title = "A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer",
abstract = "PURPOSE: The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the consensus definition for cancer cachexia in 2011, there is now a need to establish estimates of prevalence. Therefore, the primary aim of the present study was to assess the prevalence of cachexia in an unselected cancer population. A secondary aim was to assess patient-perceived need of attention to cachexia.METHODS: A cross-sectional study in hospital patients was undertaken. Key inclusion criteria were the following: age > 18 years, cancer diagnosis, and no surgery the preceding 24 h. Data on demographics, disease, performance status, symptoms, cachexia, and patients' perceived need of attention to weight loss and nutrition were registered.RESULTS: Data were available on 386 of 426 eligible patients. Median age (IQR) was 65 years (56-72), 214 (55{\%}) were male and 302 (78{\%}) had a performance status of 0-1 (Eastern Cooperative Oncology Group). Prevalence of cachexia (inpatients/outpatients) was 51/22{\%}. Prevalence was highest in patients with gastrointestinal cancer (62/42{\%}) and lung cancer (83/36{\%}). There was no major difference in prevalence between patients with metastatic (55/24{\%}) and localized disease (47/19{\%}). Twenty percent of inpatients and 15{\%} of outpatients wanted more attention to weight loss and nutrition. Cachexia (p < 0.001), symptoms of mood disorder (p < 0.001), and male gender (p < 0.01) were independently associated with increased need of attention.CONCLUSION: Cachexia is a prevalent condition, affecting both patients with localized and metastatic cancer. Clinical attention to the condition is a sizeable unmet need.",
author = "Vagnildhaug, {Ola Magne} and Balstad, {Trude Rakel} and Almberg, {Sigrun Saur} and Cinzia Brunelli and Knudsen, {Anne Kari} and Stein Kaasa and Morten Thron{\ae}s and Barry Laird and Solheim, {Tora Skeidsvoll}",
year = "2018",
month = "6",
doi = "10.1007/s00520-017-4022-z",
language = "English",
volume = "26",
pages = "1871--1880",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer

AU - Vagnildhaug, Ola Magne

AU - Balstad, Trude Rakel

AU - Almberg, Sigrun Saur

AU - Brunelli, Cinzia

AU - Knudsen, Anne Kari

AU - Kaasa, Stein

AU - Thronæs, Morten

AU - Laird, Barry

AU - Solheim, Tora Skeidsvoll

PY - 2018/6

Y1 - 2018/6

N2 - PURPOSE: The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the consensus definition for cancer cachexia in 2011, there is now a need to establish estimates of prevalence. Therefore, the primary aim of the present study was to assess the prevalence of cachexia in an unselected cancer population. A secondary aim was to assess patient-perceived need of attention to cachexia.METHODS: A cross-sectional study in hospital patients was undertaken. Key inclusion criteria were the following: age > 18 years, cancer diagnosis, and no surgery the preceding 24 h. Data on demographics, disease, performance status, symptoms, cachexia, and patients' perceived need of attention to weight loss and nutrition were registered.RESULTS: Data were available on 386 of 426 eligible patients. Median age (IQR) was 65 years (56-72), 214 (55%) were male and 302 (78%) had a performance status of 0-1 (Eastern Cooperative Oncology Group). Prevalence of cachexia (inpatients/outpatients) was 51/22%. Prevalence was highest in patients with gastrointestinal cancer (62/42%) and lung cancer (83/36%). There was no major difference in prevalence between patients with metastatic (55/24%) and localized disease (47/19%). Twenty percent of inpatients and 15% of outpatients wanted more attention to weight loss and nutrition. Cachexia (p < 0.001), symptoms of mood disorder (p < 0.001), and male gender (p < 0.01) were independently associated with increased need of attention.CONCLUSION: Cachexia is a prevalent condition, affecting both patients with localized and metastatic cancer. Clinical attention to the condition is a sizeable unmet need.

AB - PURPOSE: The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the consensus definition for cancer cachexia in 2011, there is now a need to establish estimates of prevalence. Therefore, the primary aim of the present study was to assess the prevalence of cachexia in an unselected cancer population. A secondary aim was to assess patient-perceived need of attention to cachexia.METHODS: A cross-sectional study in hospital patients was undertaken. Key inclusion criteria were the following: age > 18 years, cancer diagnosis, and no surgery the preceding 24 h. Data on demographics, disease, performance status, symptoms, cachexia, and patients' perceived need of attention to weight loss and nutrition were registered.RESULTS: Data were available on 386 of 426 eligible patients. Median age (IQR) was 65 years (56-72), 214 (55%) were male and 302 (78%) had a performance status of 0-1 (Eastern Cooperative Oncology Group). Prevalence of cachexia (inpatients/outpatients) was 51/22%. Prevalence was highest in patients with gastrointestinal cancer (62/42%) and lung cancer (83/36%). There was no major difference in prevalence between patients with metastatic (55/24%) and localized disease (47/19%). Twenty percent of inpatients and 15% of outpatients wanted more attention to weight loss and nutrition. Cachexia (p < 0.001), symptoms of mood disorder (p < 0.001), and male gender (p < 0.01) were independently associated with increased need of attention.CONCLUSION: Cachexia is a prevalent condition, affecting both patients with localized and metastatic cancer. Clinical attention to the condition is a sizeable unmet need.

U2 - 10.1007/s00520-017-4022-z

DO - 10.1007/s00520-017-4022-z

M3 - Article

C2 - 29274028

VL - 26

SP - 1871

EP - 1880

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 6

ER -