A cytogenetic, phenotypic, and molecular study of an immunoblastic lymphoma with a 14q+ translocation

G. Sozzi, A. Agresti, M. G. Bertoglio, M. G. Borrello, D. Delia, R. Giardini, M. A. Pierotti, F. Rilke, G. Delia Porta

Research output: Contribution to journalArticlepeer-review

Abstract

An uncultured immunoblastic lymphoma, obtained from an untreated patient, was examined from a cytogenetic, immunophenotypic, and molecular viewpoint. The B-cell lineage, immunoglobulin Iight-chain type, and percentage of neoplastic cells were determined immunologically. Karyotyping showed the presence of a 14q+ marker and suggested that the donor chromosome was chromosome 8. Southern-blot analysis of DNA from normal and lymphoma cells, using as molecular probes sequences related to the IGHJ and IGK immunoglobulin genes, confirmed the immunophenotype. A similar analysis, using probes homologous to IGHAC and MYC genes, showed that the t (8; 14) detected by cytogenetic analysis resulted in a IGHAC-MYC rearrangement.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalCytogenetic and Genome Research
Volume45
Issue number3-4
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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