A Delphi consensus and open debate on the role of first-line bevacizumab for HER2-negative metastatic breast cancer

Fabio Puglisi, Giancarlo Bisagni, Mariangela Ciccarese, Caterina Fontanella, Teresa Gamucci, Luigi Leo, Annamaria Molino, Rosa Rita Silva, Paolo Marchetti

Research output: Contribution to journalReview article

Abstract

To gain consensus on the role of bevacizumab plus paclitaxel as first-line treatment for HER2-negative metastatic breast cancer, a panel of expert oncologists experienced in treating patients with metastatic breast cancer in Italy participated in a Delphi consensus study. The panel reached a full consensus on the efficacy of bevacizumab plus paclitaxel and the clinical meaningfulness of the progression-free survival benefit compared with paclitaxel alone, despite the lack of an overall survival effect in clinical trials. The participants agreed that real-world data support the effectiveness and well-defined safety profile of the regimen. Views on the use of bevacizumab plus paclitaxel in specific patient populations were not unanimous and clinical judgment remains important. Nevertheless, a high level of agreement was reached.

Original languageEnglish
Pages (from-to)2589-2602
Number of pages14
JournalFuture Oncology
Volume12
Issue number22
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Paclitaxel
Consensus
Breast Neoplasms
Delphi Technique
Italy
Disease-Free Survival
Clinical Trials
Safety
Survival
Bevacizumab
Population
Therapeutics

Keywords

  • angiogenesis
  • bevacizumab
  • breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A Delphi consensus and open debate on the role of first-line bevacizumab for HER2-negative metastatic breast cancer. / Puglisi, Fabio; Bisagni, Giancarlo; Ciccarese, Mariangela; Fontanella, Caterina; Gamucci, Teresa; Leo, Luigi; Molino, Annamaria; Silva, Rosa Rita; Marchetti, Paolo.

In: Future Oncology, Vol. 12, No. 22, 01.11.2016, p. 2589-2602.

Research output: Contribution to journalReview article

Puglisi, F, Bisagni, G, Ciccarese, M, Fontanella, C, Gamucci, T, Leo, L, Molino, A, Silva, RR & Marchetti, P 2016, 'A Delphi consensus and open debate on the role of first-line bevacizumab for HER2-negative metastatic breast cancer', Future Oncology, vol. 12, no. 22, pp. 2589-2602. https://doi.org/10.2217/fon-2016-0295
Puglisi, Fabio ; Bisagni, Giancarlo ; Ciccarese, Mariangela ; Fontanella, Caterina ; Gamucci, Teresa ; Leo, Luigi ; Molino, Annamaria ; Silva, Rosa Rita ; Marchetti, Paolo. / A Delphi consensus and open debate on the role of first-line bevacizumab for HER2-negative metastatic breast cancer. In: Future Oncology. 2016 ; Vol. 12, No. 22. pp. 2589-2602.
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