A description of two cases of factor V deficiency

FEDERICO CERNECA, ERGIO PARCO, ROBERT SIMEONE, BRUNO BEMBI, RITA GIORGI

Research output: Contribution to journalArticlepeer-review

Abstract

Summary We report two cases of factor V deficiency. A 12‐year‐old girl with thalassemia major was admitted for bone marrow transplant (mismatched). She was found to have a heterozygous deficiency of factor V (21%), but this was considered compatible with the transplant, which was performed without the support of suppernatant cryoprecipitate. A 14‐year‐old girl (factor V 2%) with a negative history (menarche at age 12, menstrual cycle regular and normal in quantity and length). One year previously she had complained of menorrhagia (length of period, 9 days); tests revealed server anaemia (Hb 4.9 g/dl). We show how even severe cases of factor V deficiency may often be silent, and not require transfusion in surgical procedures, thus avoiding the risks associated with such therapy.

Original languageEnglish
Pages (from-to)200-201
Number of pages2
JournalHaemophilia
Volume1
Issue number3
DOIs
Publication statusPublished - 1995

Keywords

  • bone marrow transplant
  • coagulation tests
  • factor V
  • factor V deficiency
  • menorrhagia
  • parahaemophilia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Hematology

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