A developmental and genetic classification for malformations of cortical development: Update 2012

A. James Barkovich; Renzo Guerrini; Ruben I. Kuzniecky; Graeme D. Jackson; William B. Dobyns

doi:10.1093/brain/aws019

A developmental and genetic classification for malformations of cortical development: Update 2012

A. James Barkovich, Renzo Guerrini, Ruben I. Kuzniecky, Graeme D. Jackson, William B. Dobyns

Fondazione Stella Maris

Research output: Contribution to journal › Article › peer-review

Abstract

Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain development and its perturbations. The rapid recent evolution of molecular biology, genetics and imaging has resulted in an explosive increase in our knowledge of cerebral cortex development and in the number and types of malformations of cortical development that have been reported. These advances continue to modify our perception of these malformations. This review addresses recent changes in our perception of these disorders and proposes a modified classification based upon updates in our knowledge of cerebral cortical development.

Original language	English
Pages (from-to)	1348-1369
Number of pages	22
Journal	Brain
Volume	135
Issue number	5
DOIs	https://doi.org/10.1093/brain/aws019
Publication status	Published - 2012

Keywords

cerebral cortex
cortical dysplasia
malformation of cortical development
microcephaly
polymicrogyria

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1093/brain/aws019

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AU - Dobyns, William B.

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