A device for the detection of cognitive brain functions in completely paralyzed or unresponsive patients

Thilo Hinterberger, Barbara Wilhelm, Jürgen Mellinger, Boris Kotchoubey, Niels Birbaumer

Research output: Contribution to journalArticlepeer-review


Unresponsive patients with remaining cognitive abilities may be able to communicate with a brain-computer interface (BCI) such as the Thought Translation Device (TTD). Before initiating TTD learning, which may imply considerable effort, it is important to classify the patients' state of awareness and their remaining cognitive abilities. A tool for detection of cognitive activity (DCA) in the completely paralyzed was developed and integrated into the TTD which is a psychophysiological system for direct brain communication. In the present version, DCA entails five event-related brain-potential (ERP) experiments and investigates the capability of a patient to discriminate, e.g., between semantically related and unrelated concepts and categories. ERPs serve as an indicator of the patients' cortical information processing. Data from five severely brain-injured patients in persistent vegetative state diagnosed as unresponsive and five healthy controls are presented to illustrate the methodology. Two patients showing the highest responsiveness were selected for TTD training. The DCA integrated in the TTD allows screening of cognitive abilities and direct brain communication in the patients' home.

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Issue number2
Publication statusPublished - Feb 2005


  • Brain-computer-interface (BCI)
  • Cognition
  • Event-related brain potentials (ERP)
  • Locked-in syndrome

ASJC Scopus subject areas

  • Biomedical Engineering


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