A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients

G. Fabbrocini, N. Cameli, S. Lorenzi, M. P. De Padova, C. Marasca, R. Izzo, G. Monfrecola

Research output: Contribution to journalArticlepeer-review


Aim. The purpose of the study was to analyze the potential capacity of a dietary supplement, based on gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera, to reduce side effects, in particular the dry skin, erythema and desquamation, due to treatment with oral isotretinoin, and evaluate the ability of the product to increase adherence to therapy in patients with acne.

Methods. Forty-eight patients with nodular acne (32 females and 16 males) were randomly divided into 2 groups: 24 re-ceveid isotretinoin therapy (20-30 mg/day) for 6 months associated to dietary supplement (twice a day), while the other 24 patients received only isotretinoin (20-30 mg/day) for 6 months: For all patients the degree of acne severity, through GAGS (Global Acne Grading System), the sebum production by Sebütape, the hydration by Corneometer and the erythema by Mexameter, were measured. We have also evaluated the adherence to treatment, asking to patients how many days a week they follow the therapy.

Results. Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported.

Conclusion. Thanks to antioxidant and moisturizing properties, the dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, betacarotene, coenzyme Q10 and Vitis Vitifera, can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number4
Publication statusPublished - Aug 1 2014


  • Acne vulgaris
  • Dietary supplements
  • Isotretinoin

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)


Dive into the research topics of 'A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients'. Together they form a unique fingerprint.

Cite this