SU UN NBT TEST DIFFERENZIALE NELLA DIAGNOSTICA DELLE MALATTIE INFETTIVE

Translated title of the contribution: A differential nitroblue tetrazolium test in the diagnosis of infectious diseases

E. Magliulo, D. Scevola, A. Bertotto, A. Faga

Research output: Contribution to journalArticlepeer-review

Abstract

A differential NBT (nitroblue tetrazolium) qualitative test was separately performed on neutrophil granulocytes and monocytes in a number of healthy controls and in bacterial, mycotic, protozoal and viral infections. Whereas the test on both cell types was negative in healthy controls (frequency of cells spontaneously reducing the dye by less than 8%), increased spontaneous reduction at levels of test positivity (>8%) constituted a more constant feature of monocytes than of granulocytes in the infectious conditions. This was particularly true of viral infections where the test was positive on monocytes even when negative on granulocytes. These phenomena, together with the particularly strong positivity of the NBT test on monocytes of patients infected with pathogens (brucellae, salmonellae, toxoplasma) behaving as intracellular parasites, probably reflect undefined kinds of interaction between the infecting agents and mononuclear phagocytes.

Translated title of the contributionA differential nitroblue tetrazolium test in the diagnosis of infectious diseases
Original languageItalian
Pages (from-to)230-234
Number of pages5
JournalGiornale di Malattie Infettive e Parassitarie
Volume27
Issue number3
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Parasitology

Fingerprint Dive into the research topics of 'A differential nitroblue tetrazolium test in the diagnosis of infectious diseases'. Together they form a unique fingerprint.

Cite this