A diffusion tensor imaging study of suicide attempters

Doreen M. Olvet, Denis Peruzzo, Binod Thapa-Chhetry, M. Elizabeth Sublette, Gregory M. Sullivan, Maria A. Oquendo, J. John Mann, Ramin V. Parsey

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Few studies have examined white matter abnormalities in suicide attempters using diffusion tensor imaging (DTI). This study sought to identify white matter regions altered in individuals with a prior suicide attempt. Methods: DTI scans were acquired in 13 suicide attempters with major depressive disorder (MDD), 39 non-attempters with MDD, and 46 healthy participants (HP). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the brain using two methods: region of interest (ROI) and tract-based spatial statistics (TBSS). ROIs were limited a priori to white matter adjacent to the caudal anterior cingulate cortex, rostral anterior cingulate cortex, dorsomedial prefrontal cortex, and medial orbitofrontal cortex. Results: Using the ROI approach, suicide attempters had lower FA than MDD non-attempters and HP in the dorsomedial prefrontal cortex. Uncorrected TBSS results confirmed a significant cluster within the right dorsomedial prefrontal cortex indicating lower FA in suicide attempters compared to non-attempters. There were no differences in ADC when comparing suicide attempters, non-attempters and HP groups using ROI or TBSS methods. Conclusions: Low FA in the dorsomedial prefrontal cortex was associated with a suicide attempt history. Converging findings from other imaging modalities support this finding, making this region of potential interest in determining the diathesis for suicidal behavior.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalJournal of Psychiatric Research
Volume51
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Diffusion Tensor Imaging
Suicide
Prefrontal Cortex
Anisotropy
Major Depressive Disorder
Healthy Volunteers
Gyrus Cinguli
Disease Susceptibility
Imaging
History
Brain
White Matter
Cortex
Spatial Statistics

Keywords

  • Diffusion tensor imaging
  • Dorsomedial prefrontal cortex
  • Major depressive disorder
  • Suicide attempt
  • Tract-based spatial statistics
  • White matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Arts and Humanities (miscellaneous)

Cite this

Olvet, D. M., Peruzzo, D., Thapa-Chhetry, B., Sublette, M. E., Sullivan, G. M., Oquendo, M. A., ... Parsey, R. V. (2014). A diffusion tensor imaging study of suicide attempters. Journal of Psychiatric Research, 51(1), 60-67. https://doi.org/10.1016/j.jpsychires.2014.01.002

A diffusion tensor imaging study of suicide attempters. / Olvet, Doreen M.; Peruzzo, Denis; Thapa-Chhetry, Binod; Sublette, M. Elizabeth; Sullivan, Gregory M.; Oquendo, Maria A.; Mann, J. John; Parsey, Ramin V.

In: Journal of Psychiatric Research, Vol. 51, No. 1, 2014, p. 60-67.

Research output: Contribution to journalArticle

Olvet, DM, Peruzzo, D, Thapa-Chhetry, B, Sublette, ME, Sullivan, GM, Oquendo, MA, Mann, JJ & Parsey, RV 2014, 'A diffusion tensor imaging study of suicide attempters', Journal of Psychiatric Research, vol. 51, no. 1, pp. 60-67. https://doi.org/10.1016/j.jpsychires.2014.01.002
Olvet, Doreen M. ; Peruzzo, Denis ; Thapa-Chhetry, Binod ; Sublette, M. Elizabeth ; Sullivan, Gregory M. ; Oquendo, Maria A. ; Mann, J. John ; Parsey, Ramin V. / A diffusion tensor imaging study of suicide attempters. In: Journal of Psychiatric Research. 2014 ; Vol. 51, No. 1. pp. 60-67.
@article{2fe680f1b5e14ddc9c24476714f67169,
title = "A diffusion tensor imaging study of suicide attempters",
abstract = "Background: Few studies have examined white matter abnormalities in suicide attempters using diffusion tensor imaging (DTI). This study sought to identify white matter regions altered in individuals with a prior suicide attempt. Methods: DTI scans were acquired in 13 suicide attempters with major depressive disorder (MDD), 39 non-attempters with MDD, and 46 healthy participants (HP). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the brain using two methods: region of interest (ROI) and tract-based spatial statistics (TBSS). ROIs were limited a priori to white matter adjacent to the caudal anterior cingulate cortex, rostral anterior cingulate cortex, dorsomedial prefrontal cortex, and medial orbitofrontal cortex. Results: Using the ROI approach, suicide attempters had lower FA than MDD non-attempters and HP in the dorsomedial prefrontal cortex. Uncorrected TBSS results confirmed a significant cluster within the right dorsomedial prefrontal cortex indicating lower FA in suicide attempters compared to non-attempters. There were no differences in ADC when comparing suicide attempters, non-attempters and HP groups using ROI or TBSS methods. Conclusions: Low FA in the dorsomedial prefrontal cortex was associated with a suicide attempt history. Converging findings from other imaging modalities support this finding, making this region of potential interest in determining the diathesis for suicidal behavior.",
keywords = "Diffusion tensor imaging, Dorsomedial prefrontal cortex, Major depressive disorder, Suicide attempt, Tract-based spatial statistics, White matter",
author = "Olvet, {Doreen M.} and Denis Peruzzo and Binod Thapa-Chhetry and Sublette, {M. Elizabeth} and Sullivan, {Gregory M.} and Oquendo, {Maria A.} and Mann, {J. John} and Parsey, {Ramin V.}",
year = "2014",
doi = "10.1016/j.jpsychires.2014.01.002",
language = "English",
volume = "51",
pages = "60--67",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - A diffusion tensor imaging study of suicide attempters

AU - Olvet, Doreen M.

AU - Peruzzo, Denis

AU - Thapa-Chhetry, Binod

AU - Sublette, M. Elizabeth

AU - Sullivan, Gregory M.

AU - Oquendo, Maria A.

AU - Mann, J. John

AU - Parsey, Ramin V.

PY - 2014

Y1 - 2014

N2 - Background: Few studies have examined white matter abnormalities in suicide attempters using diffusion tensor imaging (DTI). This study sought to identify white matter regions altered in individuals with a prior suicide attempt. Methods: DTI scans were acquired in 13 suicide attempters with major depressive disorder (MDD), 39 non-attempters with MDD, and 46 healthy participants (HP). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the brain using two methods: region of interest (ROI) and tract-based spatial statistics (TBSS). ROIs were limited a priori to white matter adjacent to the caudal anterior cingulate cortex, rostral anterior cingulate cortex, dorsomedial prefrontal cortex, and medial orbitofrontal cortex. Results: Using the ROI approach, suicide attempters had lower FA than MDD non-attempters and HP in the dorsomedial prefrontal cortex. Uncorrected TBSS results confirmed a significant cluster within the right dorsomedial prefrontal cortex indicating lower FA in suicide attempters compared to non-attempters. There were no differences in ADC when comparing suicide attempters, non-attempters and HP groups using ROI or TBSS methods. Conclusions: Low FA in the dorsomedial prefrontal cortex was associated with a suicide attempt history. Converging findings from other imaging modalities support this finding, making this region of potential interest in determining the diathesis for suicidal behavior.

AB - Background: Few studies have examined white matter abnormalities in suicide attempters using diffusion tensor imaging (DTI). This study sought to identify white matter regions altered in individuals with a prior suicide attempt. Methods: DTI scans were acquired in 13 suicide attempters with major depressive disorder (MDD), 39 non-attempters with MDD, and 46 healthy participants (HP). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the brain using two methods: region of interest (ROI) and tract-based spatial statistics (TBSS). ROIs were limited a priori to white matter adjacent to the caudal anterior cingulate cortex, rostral anterior cingulate cortex, dorsomedial prefrontal cortex, and medial orbitofrontal cortex. Results: Using the ROI approach, suicide attempters had lower FA than MDD non-attempters and HP in the dorsomedial prefrontal cortex. Uncorrected TBSS results confirmed a significant cluster within the right dorsomedial prefrontal cortex indicating lower FA in suicide attempters compared to non-attempters. There were no differences in ADC when comparing suicide attempters, non-attempters and HP groups using ROI or TBSS methods. Conclusions: Low FA in the dorsomedial prefrontal cortex was associated with a suicide attempt history. Converging findings from other imaging modalities support this finding, making this region of potential interest in determining the diathesis for suicidal behavior.

KW - Diffusion tensor imaging

KW - Dorsomedial prefrontal cortex

KW - Major depressive disorder

KW - Suicide attempt

KW - Tract-based spatial statistics

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=84893920952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893920952&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2014.01.002

DO - 10.1016/j.jpsychires.2014.01.002

M3 - Article

VL - 51

SP - 60

EP - 67

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 1

ER -