A diffusion tensor magnetic resonance imaging study of paediatric patients with severe non-traumatic brain injury

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Abstract

AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury.

METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo). Fractional anisotropy, mean, axial, and radial diffusivities were calculated for the corpus callosum, inferior, middle (MCP), and superior cerebellar peduncles (SCP).

RESULTS: DT-MRI parameters from corpus callosum and SCP differed between patients and controls. MCP abnormalities were detected in patients presenting non-traumatic composite aetiology (n=4) versus those suffering from pure anoxia (n=9). The supra-tentorial compartment was more damaged (i.e. decreased fractional anisotropy and increased diffusivities) than the infra-tentorial one. Correlations were found between DT-MRI abnormalities and Glasgow Outcome Scale scores.

INTERPRETATION: In paediatric UWS/MCS, the severity of clinical disability correlates with white matter tract abnormalities.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2017

Fingerprint

Diffusion Magnetic Resonance Imaging
Brain Injuries
Pediatrics
Corpus Callosum
Anisotropy
Glasgow Outcome Scale
Persistent Vegetative State
Wakefulness
Consciousness
Observational Studies
Pathology
White Matter

Keywords

  • Adolescent
  • Analysis of Variance
  • Anisotropy
  • Brain Injuries
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Neural Pathways
  • Severity of Illness Index
  • Statistics as Topic
  • White Matter
  • Journal Article
  • Observational Study

Cite this

@article{13bdf8fb5c0d453e8ef1d75e9ae00404,
title = "A diffusion tensor magnetic resonance imaging study of paediatric patients with severe non-traumatic brain injury",
abstract = "AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury.METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo). Fractional anisotropy, mean, axial, and radial diffusivities were calculated for the corpus callosum, inferior, middle (MCP), and superior cerebellar peduncles (SCP).RESULTS: DT-MRI parameters from corpus callosum and SCP differed between patients and controls. MCP abnormalities were detected in patients presenting non-traumatic composite aetiology (n=4) versus those suffering from pure anoxia (n=9). The supra-tentorial compartment was more damaged (i.e. decreased fractional anisotropy and increased diffusivities) than the infra-tentorial one. Correlations were found between DT-MRI abnormalities and Glasgow Outcome Scale scores.INTERPRETATION: In paediatric UWS/MCS, the severity of clinical disability correlates with white matter tract abnormalities.",
keywords = "Adolescent, Analysis of Variance, Anisotropy, Brain Injuries, Case-Control Studies, Child, Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways, Severity of Illness Index, Statistics as Topic, White Matter, Journal Article, Observational Study",
author = "Erika Molteni and Rocca, {Maria A} and Sandra Strazzer and Elisabetta Pagani and Katia Colombo and Filippo Arrigoni and Giacomo Boffa and Massimiliano Copetti and Valentina Pastore and Massimo Filippi",
note = "{\circledC} 2016 Mac Keith Press.",
year = "2017",
month = "2",
doi = "10.1111/dmcn.13332",
language = "English",
volume = "59",
pages = "199--206",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
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number = "2",

}

TY - JOUR

T1 - A diffusion tensor magnetic resonance imaging study of paediatric patients with severe non-traumatic brain injury

AU - Molteni, Erika

AU - Rocca, Maria A

AU - Strazzer, Sandra

AU - Pagani, Elisabetta

AU - Colombo, Katia

AU - Arrigoni, Filippo

AU - Boffa, Giacomo

AU - Copetti, Massimiliano

AU - Pastore, Valentina

AU - Filippi, Massimo

N1 - © 2016 Mac Keith Press.

PY - 2017/2

Y1 - 2017/2

N2 - AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury.METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo). Fractional anisotropy, mean, axial, and radial diffusivities were calculated for the corpus callosum, inferior, middle (MCP), and superior cerebellar peduncles (SCP).RESULTS: DT-MRI parameters from corpus callosum and SCP differed between patients and controls. MCP abnormalities were detected in patients presenting non-traumatic composite aetiology (n=4) versus those suffering from pure anoxia (n=9). The supra-tentorial compartment was more damaged (i.e. decreased fractional anisotropy and increased diffusivities) than the infra-tentorial one. Correlations were found between DT-MRI abnormalities and Glasgow Outcome Scale scores.INTERPRETATION: In paediatric UWS/MCS, the severity of clinical disability correlates with white matter tract abnormalities.

AB - AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury.METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo). Fractional anisotropy, mean, axial, and radial diffusivities were calculated for the corpus callosum, inferior, middle (MCP), and superior cerebellar peduncles (SCP).RESULTS: DT-MRI parameters from corpus callosum and SCP differed between patients and controls. MCP abnormalities were detected in patients presenting non-traumatic composite aetiology (n=4) versus those suffering from pure anoxia (n=9). The supra-tentorial compartment was more damaged (i.e. decreased fractional anisotropy and increased diffusivities) than the infra-tentorial one. Correlations were found between DT-MRI abnormalities and Glasgow Outcome Scale scores.INTERPRETATION: In paediatric UWS/MCS, the severity of clinical disability correlates with white matter tract abnormalities.

KW - Adolescent

KW - Analysis of Variance

KW - Anisotropy

KW - Brain Injuries

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Neural Pathways

KW - Severity of Illness Index

KW - Statistics as Topic

KW - White Matter

KW - Journal Article

KW - Observational Study

U2 - 10.1111/dmcn.13332

DO - 10.1111/dmcn.13332

M3 - Article

C2 - 27910995

VL - 59

SP - 199

EP - 206

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

IS - 2

ER -