A diffusion tensor MRI study of basal ganglia from patients with ADEM

Markus Holtmannspötter, Matilde Inglese, Marco Rovaris, Maria Assunta Rocca, Maria Codella, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity (D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ (p=0.02) and lower D̄ histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalJournal of the Neurological Sciences
Issue number1
Publication statusPublished - Jan 15 2003


  • Acute disseminated encephalomyelitis
  • Basal ganglia
  • Diffusion tensor MRI
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)


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