A diffusion weighted imaging study of basal ganglia in schizophrenia

Giuseppe Delvecchio, Alessandro Pigoni, Cinzia Perlini, Marco Barillari, Amelia Versace, Mirella Ruggeri, A. Carlo Altamura, Marcella Bellani, Paolo Brambilla

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Several magnetic resonance imaging (MRI) studies provided evidence of selective brain abnormalities in schizophrenia, both in cortical and subcortical structures. Basal ganglia are of particular interest, given not only the high concentration of dopaminergic neurons and receptors, but also for their crucial role in cognitive functions, commonly impaired in schizophrenia. To date, very few studies explored basal ganglia using diffusion imaging, which is sensitive to microstructural organization in brain tissues. The aim of our study is to explore basal ganglia structures with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls. Methods: We enrolled 52 subjects affected by schizophrenia according to DMS-IV-R criteria and 46 healthy controls. Diffusion weighted images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined in axial and coronal sections at the level of basal ganglia. Results: Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus (F = 3.9, p = .05). A significant positive correlation between right anterior lenticular nucleus and psychotropic dosages was found (r = 0.4, p = .01). Conclusions: Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.Key pointsThe basal ganglia structures was explored with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls.Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus.Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalInternational Journal of Psychiatry in Clinical Practice
Volume22
Issue number1
DOIs
Publication statusPublished - 2018

Fingerprint

Basal Ganglia
Schizophrenia
Corpus Striatum
Dopaminergic Neurons
Brain
Cognition
Magnetic Resonance Imaging

Keywords

  • apparent diffusion coefficient
  • basal ganglia
  • diffusion-weighted imaging
  • lenticular nucleus
  • magnetic resonance imaging
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A diffusion weighted imaging study of basal ganglia in schizophrenia. / Delvecchio, Giuseppe; Pigoni, Alessandro; Perlini, Cinzia; Barillari, Marco; Versace, Amelia; Ruggeri, Mirella; Altamura, A. Carlo; Bellani, Marcella; Brambilla, Paolo.

In: International Journal of Psychiatry in Clinical Practice, Vol. 22, No. 1, 2018, p. 6-12.

Research output: Contribution to journalArticle

Delvecchio, Giuseppe ; Pigoni, Alessandro ; Perlini, Cinzia ; Barillari, Marco ; Versace, Amelia ; Ruggeri, Mirella ; Altamura, A. Carlo ; Bellani, Marcella ; Brambilla, Paolo. / A diffusion weighted imaging study of basal ganglia in schizophrenia. In: International Journal of Psychiatry in Clinical Practice. 2018 ; Vol. 22, No. 1. pp. 6-12.
@article{602dd5b527394f7e928c190519cd9443,
title = "A diffusion weighted imaging study of basal ganglia in schizophrenia",
abstract = "Objectives: Several magnetic resonance imaging (MRI) studies provided evidence of selective brain abnormalities in schizophrenia, both in cortical and subcortical structures. Basal ganglia are of particular interest, given not only the high concentration of dopaminergic neurons and receptors, but also for their crucial role in cognitive functions, commonly impaired in schizophrenia. To date, very few studies explored basal ganglia using diffusion imaging, which is sensitive to microstructural organization in brain tissues. The aim of our study is to explore basal ganglia structures with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls. Methods: We enrolled 52 subjects affected by schizophrenia according to DMS-IV-R criteria and 46 healthy controls. Diffusion weighted images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined in axial and coronal sections at the level of basal ganglia. Results: Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus (F = 3.9, p = .05). A significant positive correlation between right anterior lenticular nucleus and psychotropic dosages was found (r = 0.4, p = .01). Conclusions: Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.Key pointsThe basal ganglia structures was explored with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls.Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus.Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.",
keywords = "apparent diffusion coefficient, basal ganglia, diffusion-weighted imaging, lenticular nucleus, magnetic resonance imaging, Schizophrenia",
author = "Giuseppe Delvecchio and Alessandro Pigoni and Cinzia Perlini and Marco Barillari and Amelia Versace and Mirella Ruggeri and Altamura, {A. Carlo} and Marcella Bellani and Paolo Brambilla",
year = "2018",
doi = "10.1080/13651501.2017.1340650",
language = "English",
volume = "22",
pages = "6--12",
journal = "International Journal of Psychiatry in Clinical Practice",
issn = "1365-1501",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - A diffusion weighted imaging study of basal ganglia in schizophrenia

AU - Delvecchio, Giuseppe

AU - Pigoni, Alessandro

AU - Perlini, Cinzia

AU - Barillari, Marco

AU - Versace, Amelia

AU - Ruggeri, Mirella

AU - Altamura, A. Carlo

AU - Bellani, Marcella

AU - Brambilla, Paolo

PY - 2018

Y1 - 2018

N2 - Objectives: Several magnetic resonance imaging (MRI) studies provided evidence of selective brain abnormalities in schizophrenia, both in cortical and subcortical structures. Basal ganglia are of particular interest, given not only the high concentration of dopaminergic neurons and receptors, but also for their crucial role in cognitive functions, commonly impaired in schizophrenia. To date, very few studies explored basal ganglia using diffusion imaging, which is sensitive to microstructural organization in brain tissues. The aim of our study is to explore basal ganglia structures with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls. Methods: We enrolled 52 subjects affected by schizophrenia according to DMS-IV-R criteria and 46 healthy controls. Diffusion weighted images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined in axial and coronal sections at the level of basal ganglia. Results: Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus (F = 3.9, p = .05). A significant positive correlation between right anterior lenticular nucleus and psychotropic dosages was found (r = 0.4, p = .01). Conclusions: Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.Key pointsThe basal ganglia structures was explored with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls.Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus.Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.

AB - Objectives: Several magnetic resonance imaging (MRI) studies provided evidence of selective brain abnormalities in schizophrenia, both in cortical and subcortical structures. Basal ganglia are of particular interest, given not only the high concentration of dopaminergic neurons and receptors, but also for their crucial role in cognitive functions, commonly impaired in schizophrenia. To date, very few studies explored basal ganglia using diffusion imaging, which is sensitive to microstructural organization in brain tissues. The aim of our study is to explore basal ganglia structures with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls. Methods: We enrolled 52 subjects affected by schizophrenia according to DMS-IV-R criteria and 46 healthy controls. Diffusion weighted images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined in axial and coronal sections at the level of basal ganglia. Results: Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus (F = 3.9, p = .05). A significant positive correlation between right anterior lenticular nucleus and psychotropic dosages was found (r = 0.4, p = .01). Conclusions: Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.Key pointsThe basal ganglia structures was explored with diffusion imaging in a sizeable sample of patients affected by schizophrenia and healthy controls.Patients affected by schizophrenia showed a significantly higher ADC compared to healthy controls in the left anterior lenticular nucleus.Our study provides evidence of lenticular nucleus microstructure alterations in schizophrenia, potentially sustaining cognitive and motor deficits in schizophrenia.

KW - apparent diffusion coefficient

KW - basal ganglia

KW - diffusion-weighted imaging

KW - lenticular nucleus

KW - magnetic resonance imaging

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85021192749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021192749&partnerID=8YFLogxK

U2 - 10.1080/13651501.2017.1340650

DO - 10.1080/13651501.2017.1340650

M3 - Article

VL - 22

SP - 6

EP - 12

JO - International Journal of Psychiatry in Clinical Practice

JF - International Journal of Psychiatry in Clinical Practice

SN - 1365-1501

IS - 1

ER -