TY - JOUR
T1 - A direct cortico-nigral pathway as revealed by constrained spherical deconvolution tractography in humans
AU - Cacciola, Alberto
AU - Milardi, Demetrio
AU - Anastasi, Giuseppe P.
AU - Basile, Gianpaolo A.
AU - Ciolli, Pietro
AU - Irrera, Mariangela
AU - Cutroneo, Giuseppina
AU - Bruschetta, Daniele
AU - Rizzo, Giuseppina
AU - Mondello, Stefania
AU - Bramanti, Placido
AU - Quartarone, Angelo
PY - 2016/7/26
Y1 - 2016/7/26
N2 - Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway. Although its subcortical connections are relatively well-known in human brain, little is known about its cortical connections. The existence of a direct cortico-nigral pathway has been demonstrated in rodents and primates but only hypothesized in humans. In this study, we aimed at evaluating cortical connections of substantia nigra in vivo in human brain by using probabilistic constrained spherical deconvolution (CSD) tractography on magnetic resonance diffusion weighted imaging data. We found that substantia nigra is connected with cerebral cortex as a whole, with the most representative connections involving prefrontal cortex, precentral and postcentral gyri and superior parietal lobule. These results may be relevant for the comprehension of the pathophysiology of several neurological disorders involving substantia nigra, such as parkinson's disease, schizophrenia, and pathological addictions.
AB - Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway. Although its subcortical connections are relatively well-known in human brain, little is known about its cortical connections. The existence of a direct cortico-nigral pathway has been demonstrated in rodents and primates but only hypothesized in humans. In this study, we aimed at evaluating cortical connections of substantia nigra in vivo in human brain by using probabilistic constrained spherical deconvolution (CSD) tractography on magnetic resonance diffusion weighted imaging data. We found that substantia nigra is connected with cerebral cortex as a whole, with the most representative connections involving prefrontal cortex, precentral and postcentral gyri and superior parietal lobule. These results may be relevant for the comprehension of the pathophysiology of several neurological disorders involving substantia nigra, such as parkinson's disease, schizophrenia, and pathological addictions.
KW - Basal ganglia
KW - Connectivity
KW - Cortex
KW - CSD
KW - Parkinson disease
KW - Substantia nigra
KW - Tractography
UR - http://www.scopus.com/inward/record.url?scp=84983801012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983801012&partnerID=8YFLogxK
U2 - 10.3389/fncel.2016.00374
DO - 10.3389/fncel.2016.00374
M3 - Article
AN - SCOPUS:84983801012
VL - 10
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
SN - 1662-5161
IS - JULY2016
M1 - 374
ER -