A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Hélio José Coelho-Junior, Maurizio Bossola, Andrea Urbani, Francesco Landi, Roberto Bernabei, Emanuele Marzetti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the "BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons" (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

Original languageEnglish
JournalNutrients
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 6 2018

Fingerprint

sarcopenia
Sarcopenia
Amino Acids
amino acids
citrulline
ethanolamine
Sarcosine
amino acid metabolism
taurine
Aminobutyrates
asparagine
aspartic acid
protein metabolism
Citrulline
glutamic acid
Ethanolamine
Asparagine
Taurine
methionine
biomarkers

Keywords

  • aging
  • biomarkers
  • metabolism
  • metabolomics
  • multi-marker
  • multivariate
  • muscle
  • physical performance
  • profiling
  • protein

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia : Results from the BIOSPHERE Study. / Calvani, Riccardo; Picca, Anna; Marini, Federico; Biancolillo, Alessandra; Gervasoni, Jacopo; Persichilli, Silvia; Primiano, Aniello; Coelho-Junior, Hélio José; Bossola, Maurizio; Urbani, Andrea; Landi, Francesco; Bernabei, Roberto; Marzetti, Emanuele.

In: Nutrients, Vol. 10, No. 11, 06.11.2018.

Research output: Contribution to journalArticle

Calvani, Riccardo ; Picca, Anna ; Marini, Federico ; Biancolillo, Alessandra ; Gervasoni, Jacopo ; Persichilli, Silvia ; Primiano, Aniello ; Coelho-Junior, Hélio José ; Bossola, Maurizio ; Urbani, Andrea ; Landi, Francesco ; Bernabei, Roberto ; Marzetti, Emanuele. / A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia : Results from the BIOSPHERE Study. In: Nutrients. 2018 ; Vol. 10, No. 11.
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