A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia

Results from the BIOSPHERE Study

Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Hélio José Coelho-Junior, Maurizio Bossola, Andrea Urbani, Francesco Landi, Roberto Bernabei, Emanuele Marzetti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the "BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons" (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

Original languageEnglish
JournalNutrients
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 6 2018

Fingerprint

sarcopenia
Sarcopenia
Amino Acids
amino acids
citrulline
ethanolamine
Sarcosine
amino acid metabolism
taurine
Aminobutyrates
asparagine
aspartic acid
protein metabolism
Citrulline
glutamic acid
Ethanolamine
Asparagine
Taurine
methionine
biomarkers

Keywords

  • aging
  • biomarkers
  • metabolism
  • metabolomics
  • multi-marker
  • multivariate
  • muscle
  • physical performance
  • profiling
  • protein

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia : Results from the BIOSPHERE Study. / Calvani, Riccardo; Picca, Anna; Marini, Federico; Biancolillo, Alessandra; Gervasoni, Jacopo; Persichilli, Silvia; Primiano, Aniello; Coelho-Junior, Hélio José; Bossola, Maurizio; Urbani, Andrea; Landi, Francesco; Bernabei, Roberto; Marzetti, Emanuele.

In: Nutrients, Vol. 10, No. 11, 06.11.2018.

Research output: Contribution to journalArticle

Calvani, Riccardo ; Picca, Anna ; Marini, Federico ; Biancolillo, Alessandra ; Gervasoni, Jacopo ; Persichilli, Silvia ; Primiano, Aniello ; Coelho-Junior, Hélio José ; Bossola, Maurizio ; Urbani, Andrea ; Landi, Francesco ; Bernabei, Roberto ; Marzetti, Emanuele. / A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia : Results from the BIOSPHERE Study. In: Nutrients. 2018 ; Vol. 10, No. 11.
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abstract = "Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the {"}BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons{"} (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9{\%} (75.1 ± 4.6{\%} for enrollees with PF&S; 78.5 ± 6.0{\%} for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.",
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AU - Bossola, Maurizio

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