A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal

B. Bardoni, E. Zanaria, S. Guioli, G. Floridia, K. C. Worley, G. Tonini, E. Ferrante, G. Chiumello, E. R B McCabe, M. Fraccaro, O. Zuffardi, G. Camerino

Research output: Contribution to journalArticle

Abstract

Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute one of the causes of sex reversal in individuals with a normal 46,XY karyotype. We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the adrenal hypoplasia congenital locus. The identification of male individuals deleted for DSS suggests that this locus is not required for testis differentiation. We propose that DSS has a role in ovarian development and/or functions as a link between ovary and testis formation.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalNature Genetics
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 1994

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Bardoni, B., Zanaria, E., Guioli, S., Floridia, G., Worley, K. C., Tonini, G., Ferrante, E., Chiumello, G., McCabe, E. R. B., Fraccaro, M., Zuffardi, O., & Camerino, G. (1994). A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nature Genetics, 7(4), 497-501. https://doi.org/10.1038/ng0894-497