A dose determination procedure by PET monitoring in proton therapy: Monte carlo validation

Marco Aiello, Francesca Attanasi, Nicola Belcari, Valeria Rosso, Katrin Straub, Alberto Del Guerra

Research output: Contribution to journalArticlepeer-review


The selective energy deposition of hadrontherapy has led to a growing interest in quality assurance techniques of dose delivery. In particular, the interest in Positron Emission Tomography (PET) as a tool for treatment verification in proton therapy has become widespread in the last years and several research groups worldwide are currently investigating its clinical implementation. The aim of this work is to present an unfolding procedure which, starting from the β+ activity distribution of 11C measured with PET, leads to an estimation of the delivered dose, thus allowing a direct comparison with the planned one. The foundation of the proposed method is a filtering approach which describes the induced activity as a convolution of the dose distribution with a well defined filter function. As a solution we propose a method based on the Tikhonov theory which imposes a regularization constraint to the solution. Preliminary tests have been performed with Monte Carlo (MC) simulated data on homogeneous and inhomogeneous phantoms, showing robustness and spatial accordance between the numerically reconstructed dose and the simulated one.

Original languageEnglish
Article number6555957
Pages (from-to)3298-3304
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number5
Publication statusPublished - 2013


  • Hadron therapy
  • inverse problems
  • Positron Emission Tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics


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