TY - JOUR
T1 - A double-blind, crossover study of the antihypertensive efficacy of angiotensin II-receptor antagonists and their activation of the renin-angiotensin system
AU - Fogari, Roberte
AU - Mugellini, Amedeo
AU - Zoppi, Annalisa
AU - Fogari, Elena
AU - Marasi, Gianluigi
AU - Pesce, Rosa Maria
AU - Banderali, Alessandra
PY - 2000
Y1 - 2000
N2 - Objective: The objectives of this study were to assess the effects of 4 angiotensin II-receptor antagonists - losartan, valsartan, irbesartan, and candesartan - on blood pressure (BP) and plasma active renin (PAR), and to determine whether equipotent antihypertensive doses of these drugs produce different degrees of reactive activation of the renin-angiotensin system (RAS). Methods: This double-blind, crossover study included 40 patients with mild to moderate hypertension (diastolic BP [DBP] >90 and 90 mm Hg or a reduction in DBP of
AB - Objective: The objectives of this study were to assess the effects of 4 angiotensin II-receptor antagonists - losartan, valsartan, irbesartan, and candesartan - on blood pressure (BP) and plasma active renin (PAR), and to determine whether equipotent antihypertensive doses of these drugs produce different degrees of reactive activation of the renin-angiotensin system (RAS). Methods: This double-blind, crossover study included 40 patients with mild to moderate hypertension (diastolic BP [DBP] >90 and 90 mm Hg or a reduction in DBP of
KW - Angiotensin II-receptor antagonists
KW - Equipotent doses
KW - Plasma active renin
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U2 - 10.1016/S0011-393X(00)80047-8
DO - 10.1016/S0011-393X(00)80047-8
M3 - Article
AN - SCOPUS:0033753375
VL - 61
SP - 669
EP - 679
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 10
ER -