A double-blind, crossover study of the antihypertensive efficacy of angiotensin II-receptor antagonists and their activation of the renin-angiotensin system

Roberte Fogari, Amedeo Mugellini, Annalisa Zoppi, Elena Fogari, Gianluigi Marasi, Rosa Maria Pesce, Alessandra Banderali

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objectives of this study were to assess the effects of 4 angiotensin II-receptor antagonists - losartan, valsartan, irbesartan, and candesartan - on blood pressure (BP) and plasma active renin (PAR), and to determine whether equipotent antihypertensive doses of these drugs produce different degrees of reactive activation of the renin-angiotensin system (RAS). Methods: This double-blind, crossover study included 40 patients with mild to moderate hypertension (diastolic BP [DBP] >90 and 90 mm Hg or a reduction in DBP of

Original languageEnglish
Pages (from-to)669-679
Number of pages11
JournalCurrent Therapeutic Research
Volume61
Issue number10
DOIs
Publication statusPublished - 2000

Keywords

  • Angiotensin II-receptor antagonists
  • Equipotent doses
  • Plasma active renin

ASJC Scopus subject areas

  • Medicine(all)

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