Abstract
In 6 anesthetized, open chest dogs, the time course of coronary blood flow during intra-coronary adenosine infusion and after its cessation were assessed. Continuous adenosine infusion (1.8 mg/min) produced in 9-15 s rapid vasodilation of similar degree to post-ischemic peak; continuing the infusion, there was a further coronary vasodilation, 1.5 time larger than the maximal hyperemic one. In this phase transient ischemia did not induce further vasodilation. Discontinuation of adenosine determined a rapid reduction of coronary flow; at this time it was possible to obtain post-ischemic reactive peak flows larger than before adenosine infusion. On the basis of these experimental results, we discuss analogies and differences with respect to an electric model of 2 variable resistances (functional vascular resistances) and a constant one (anatomical vascular resistance).
Original language | English |
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Pages (from-to) | 1009-1014 |
Number of pages | 6 |
Journal | Cardiologia |
Volume | 32 |
Issue number | 9 |
Publication status | Published - 1987 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine