A dual resistance model of adenosine vasodilation

M. Dalle Vacche, M. G. Trivella, G. Pelosi, D. Levantesi, P. Camici, M. Marzilli, A. L'Abbate

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In 6 anesthetized, open chest dogs, the time course of coronary blood flow during intra-coronary adenosine infusion and after its cessation were assessed. Continuous adenosine infusion (1.8 mg/min) produced in 9-15 s rapid vasodilation of similar degree to post-ischemic peak; continuing the infusion, there was a further coronary vasodilation, 1.5 time larger than the maximal hyperemic one. In this phase transient ischemia did not induce further vasodilation. Discontinuation of adenosine determined a rapid reduction of coronary flow; at this time it was possible to obtain post-ischemic reactive peak flows larger than before adenosine infusion. On the basis of these experimental results, we discuss analogies and differences with respect to an electric model of 2 variable resistances (functional vascular resistances) and a constant one (anatomical vascular resistance).

Original languageEnglish
Pages (from-to)1009-1014
Number of pages6
Issue number9
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Dalle Vacche, M., Trivella, M. G., Pelosi, G., Levantesi, D., Camici, P., Marzilli, M., & L'Abbate, A. (1987). A dual resistance model of adenosine vasodilation. Cardiologia, 32(9), 1009-1014.