TY - JOUR
T1 - A dual role for genetically modified lymphocytes in cancer immunotherapy
AU - Russo, Vincenzo
AU - Bondanza, Attilio
AU - Ciceri, Fabio
AU - Bregni, Marco
AU - Bordignon, Claudio
AU - Traversari, Catia
AU - Bonini, Chiara
PY - 2012/4
Y1 - 2012/4
N2 - T cells as the ultimate effectors of adaptive immune responses are currently used to treat patients affected by infectious diseases and certain tumors. Recently, T cells have been manipulated ex vivo with viral vectors coding for chimeric antigen receptors, exogenous T cell receptors, or 'suicide' genes to potentiate their efficacy and minimize possible side effects. However, the introduction of exogenous genes into T lymphocytes, particularly bacterial or viral transgene products, has occasionally produced immune-mediated elimination of transduced lymphocytes. This immune effect has recently been exploited in a trial of active immunotherapy in melanoma patients. In this opinion article, we discuss the therapeutic possibilities presented by the dual aspects of genetically modified lymphocytes used to treat cancer patients.
AB - T cells as the ultimate effectors of adaptive immune responses are currently used to treat patients affected by infectious diseases and certain tumors. Recently, T cells have been manipulated ex vivo with viral vectors coding for chimeric antigen receptors, exogenous T cell receptors, or 'suicide' genes to potentiate their efficacy and minimize possible side effects. However, the introduction of exogenous genes into T lymphocytes, particularly bacterial or viral transgene products, has occasionally produced immune-mediated elimination of transduced lymphocytes. This immune effect has recently been exploited in a trial of active immunotherapy in melanoma patients. In this opinion article, we discuss the therapeutic possibilities presented by the dual aspects of genetically modified lymphocytes used to treat cancer patients.
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U2 - 10.1016/j.molmed.2011.12.003
DO - 10.1016/j.molmed.2011.12.003
M3 - Article
C2 - 22230382
AN - SCOPUS:84859425684
VL - 18
SP - 193
EP - 200
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 4
ER -