A dynamic proteome map of B cell activation

Edwin P. Romijn, Eelco Van Anken, Claudia Maggioni, Roberto Sitia, Ineke Braakman, Albert J R Heck

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A dynamic proteomics study of B lymphoma cells undergoring terminal differentiation was carried out. It was found that B cells anticipate their secretory role in a multi-step process by clustering proteins according to temporal expression patterns. It was shown that during B cell differentiation IgM production follows rather than precedes the initial ER expansion. It was concluded that metabolic capacity and the secretory machinery expand first to accommodate the mass production of IgM that follows.

Original languageEnglish
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages485-486
Number of pages2
Publication statusPublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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ASJC Scopus subject areas

  • Spectroscopy

Cite this

Romijn, E. P., Van Anken, E., Maggioni, C., Sitia, R., Braakman, I., & Heck, A. J. R. (2002). A dynamic proteome map of B cell activation. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 485-486)