A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

D. Farini; E. Cesari; R.J. Weatheritt; G. La Sala; C. Naro; V. Pagliarini; D. Bonvissuto; V. Medici; M. Guerra; C. Di Pietro; F.R. Rizzo; A. Musella; V. Carola; D. Centonze; B.J. Blencowe; D. Marazziti; C. Sette

doi:10.1016/j.celrep.2020.107703

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

D. Farini, E. Cesari, R.J. Weatheritt, G. La Sala, C. Naro, V. Pagliarini, D. Bonvissuto, V. Medici, M. Guerra, C. Di Pietro, F.R. Rizzo, A. Musella, V. Carola, D. Centonze, B.J. Blencowe, D. Marazziti, C. Sette

Research output: Contribution to journal › Article › peer-review

Abstract

Alternative splicing contributes to all steps of brain development. Farini et al. show that maturation of the cerebellum involves a dynamic splicing program that mainly affects synaptic genes. Precocious dysregulation of this program by Sam68 ablation alters cerebellar neuronal connectivity and results in defective motor coordination and social behavior.

Original language	Undefined/Unknown
Journal	Cell Reports
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.107703
Publication status	Published - 2020

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10.1016/j.celrep.2020.107703

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Cite this

Farini, D., Cesari, E., Weatheritt, R. J., La Sala, G., Naro, C., Pagliarini, V., Bonvissuto, D., Medici, V., Guerra, M., Di Pietro, C., Rizzo, F. R., Musella, A., Carola, V., Centonze, D., Blencowe, B. J., Marazziti, D., & Sette, C. (2020). A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Cell Reports, 31(9). https://doi.org/10.1016/j.celrep.2020.107703

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. / Farini, D.; Cesari, E.; Weatheritt, R.J.; La Sala, G.; Naro, C.; Pagliarini, V.; Bonvissuto, D.; Medici, V.; Guerra, M.; Di Pietro, C.; Rizzo, F.R.; Musella, A.; Carola, V.; Centonze, D.; Blencowe, B.J.; Marazziti, D.; Sette, C.

In: Cell Reports, Vol. 31, No. 9, 2020.

Research output: Contribution to journal › Article › peer-review

Farini, D, Cesari, E, Weatheritt, RJ, La Sala, G, Naro, C, Pagliarini, V, Bonvissuto, D, Medici, V, Guerra, M, Di Pietro, C, Rizzo, FR , Musella, A , Carola, V , Centonze, D, Blencowe, BJ, Marazziti, D & Sette, C 2020, 'A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum', Cell Reports, vol. 31, no. 9. https://doi.org/10.1016/j.celrep.2020.107703

Farini, D. ; Cesari, E. ; Weatheritt, R.J. ; La Sala, G. ; Naro, C. ; Pagliarini, V. ; Bonvissuto, D. ; Medici, V. ; Guerra, M. ; Di Pietro, C. ; Rizzo, F.R. ; Musella, A. ; Carola, V. ; Centonze, D. ; Blencowe, B.J. ; Marazziti, D. ; Sette, C. / A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. In: Cell Reports. 2020 ; Vol. 31, No. 9.

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abstract = "Alternative splicing contributes to all steps of brain development. Farini et al. show that maturation of the cerebellum involves a dynamic splicing program that mainly affects synaptic genes. Precocious dysregulation of this program by Sam68 ablation alters cerebellar neuronal connectivity and results in defective motor coordination and social behavior.",

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