A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

D. Farini, E. Cesari, R.J. Weatheritt, G. La Sala, C. Naro, V. Pagliarini, D. Bonvissuto, V. Medici, M. Guerra, C. Di Pietro, F.R. Rizzo, A. Musella, V. Carola, D. Centonze, B.J. Blencowe, D. Marazziti, C. Sette

Research output: Contribution to journalArticlepeer-review

Abstract

Alternative splicing contributes to all steps of brain development. Farini et al. show that maturation of the cerebellum involves a dynamic splicing program that mainly affects synaptic genes. Precocious dysregulation of this program by Sam68 ablation alters cerebellar neuronal connectivity and results in defective motor coordination and social behavior.

Original languageEnglish
JournalCell Reports
Volume31
Issue number9
DOIs
Publication statusPublished - 2020

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