A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists

A. Rizos, A. Sauerbier, A. Antonini, D. Weintraub, P. Martinez-Martin, B. Kessel, T. Henriksen, C. Falup-Pecurariu, M. Silverdale, G. Durner, K. Røkenes Karlsen, M. Grilo, P. Odin, K. Ray Chaudhuri

Research output: Contribution to journalArticle

Abstract

Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. Methods: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal) across a broad range of disease stages and age groups was performed. Results: Four hundred and twenty-five cases were included [mean age 68.3 years (range 37–90), mean duration of disease 7.5 years (range 0–37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P <0.05) compared with any other assessed DAs except for prolonged release PPX (PPX-PR). The rate of ICDs for PPX-PR (6.6%) was significantly lower than for immediate release PPX (PPX-IR) (19.0%; P <0.05). Discontinuation rates of DA therapy due to ICDs were low. Conclusion: Our data suggest a relatively low rate of ICDs with long-acting or transdermal DAs, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalEuropean Journal of Neurology
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • dopamine agonists
  • dopamine dysregulation syndrome
  • impulse control behaviours/disorders
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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  • Cite this

    Rizos, A., Sauerbier, A., Antonini, A., Weintraub, D., Martinez-Martin, P., Kessel, B., Henriksen, T., Falup-Pecurariu, C., Silverdale, M., Durner, G., Røkenes Karlsen, K., Grilo, M., Odin, P., & Chaudhuri, K. R. (2016). A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists. European Journal of Neurology, 23(8), 1255-1261. https://doi.org/10.1111/ene.13034