A family study of schizotypal disorder

Marco Battaglia, Luana Bernardeschi, Linda Franchini, Laura Bellodi, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Direct, blind interviews were used to study the risk for and prevalence of DSM-III-R Axis I and II disorders in 93 first-degree relatives of outpatients with schizotypal personality disorder (SPD) and outpatients with other personality disorders. Risks for SPD (at a slightly loosened diagnostic threshold) and schizoid personality disorder were significantly higher in the families of probands with SPD. Schizophrenia was present only among relatives of probands with SPD, accounting for a morbid risk of 4.1 percent. Neither familial risks for mood and anxiety disorders nor the prevalence of other Axis II disorders significantly differed in the two groups of relatives. It is suggested that SPD is a familial disorder representing a phenotypic expression of liability to schizophrenia.

Original languageEnglish
Pages (from-to)33-45
Number of pages13
JournalSchizophrenia Bulletin
Issue number1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Radiation
  • Radiological and Ultrasound Technology
  • Psychiatry and Mental health
  • Neuroscience(all)


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