A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene

G. Rossi, G. Giaccone, R. Maletta, M. Morbin, R. Capobianco, M. Mangieri, A. R. Giovagnoli, A. Bizzi, C. Tomaino, M. Perri, M. Di Natale, F. Tagliavini, Orso Bugiani, A. C. Bruni

Research output: Contribution to journalArticlepeer-review

Abstract

Three members of an Italian family with autosomal dominant dementia and multiple strokes had the A713T mutation of the APP gene. The neuropathologic examination of the proband disclosed Alzheimer disease (AD) with severe cerebral amyloid angiopathy and multiple infarcts. This indicates that the A713T mutation of the APP gene, lying at the γ-secretase cleavage site, can be responsible for AD with symptomatic cerebral amyloid angiopathy.

Original languageEnglish
Pages (from-to)910-912
Number of pages3
JournalNeurology
Volume63
Issue number5
Publication statusPublished - Sep 14 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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