A fast and safe technique for sperm preparation in ICSI treatments within a randomized controlled trial (RCT).

Domenico Baldini, Annamaria Baldini, Erica Silvestris, Giovanni Vizziello, Daniele Ferri, Damiano Vizziello

Research output: Contribution to journalArticlepeer-review

Abstract

Recently a novel method based on horizontal sperm migration in injection dishes has been introduced as an additional tool for preparation of semen sample in assisted reproductive technology (ART) procedures. In the present study, we evaluated both timing and reproductive outcomes in a randomized controlled study including 1034 intra-cytoplasmic sperm injection (ICSI) procedures followed by fresh embryo transfer. Couples enrolled were divided into two sub-groups, namely conventional swim-up method (Group A), and horizontal sperm migration in injection dishes (Group B). No significant differences were found between groups with respect to fertilization rate, implantation success, clinical pregnancy outcomes and ongoing pregnancies. On the contrary, both cleavage and blastocyst rates were statistically higher in Group B, suggesting superior efficiency and safety of this innovative technique also including time-saving and cheaper costs as compared to the classical swim-up sperm preparation. Our data support the interpretation of the horizontal sperm migration as a promising procedure for semen preparation in ART cycles.

Original languageEnglish
Article number88
JournalReproductive Biology and Endocrinology
Volume18
Issue number1
DOIs
Publication statusPublished - Aug 19 2020

Keywords

  • Horizontal sperm migration
  • ICSI
  • Reproductive outcomes
  • Sperm preparation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Developmental Biology

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