Abstract
Aim: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparisonto healthy controls. Material and Methods: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients. Results: The results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. Conclusion: Further studies are necessary in order to investigatethe role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.
| Translated title of the contribution | A fast method for DEFB1-44C/G snp genotyping in brazilian patients with periodontitis |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 208-215 |
| Number of pages | 8 |
| Journal | Acta Stomatologica Croatica |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Antimicrobial cationic peptides
- DEFB1 protein
- Defensins
- Diabetes complications
- Epithelial cells
- Human
- Periodontitis
ASJC Scopus subject areas
- Dentistry(all)