Brza metoda za genotipiziranje DEFB1 - 44C/G SNP-a kod brazilskih pacijenata s parodontitisom

Translated title of the contribution: A fast method for DEFB1-44C/G snp genotyping in brazilian patients with periodontitis

Renata Cimões, Rafael Rafael Amorim Cavalcanti de Siqueira, Sergio Crovella, Paulo Roberto Eleutério de Souza, Nikos Donos

Research output: Contribution to journalArticle

Abstract

Aim: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparisonto healthy controls. Material and Methods: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients. Results: The results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. Conclusion: Further studies are necessary in order to investigatethe role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.

Translated title of the contributionA fast method for DEFB1-44C/G snp genotyping in brazilian patients with periodontitis
Original languageUndefined/Unknown
Pages (from-to)208-215
Number of pages8
JournalActa Stomatologica Croatica
Volume48
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Antimicrobial cationic peptides
  • DEFB1 protein
  • Defensins
  • Diabetes complications
  • Epithelial cells
  • Human
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'A fast method for DEFB1-44C/G snp genotyping in brazilian patients with periodontitis'. Together they form a unique fingerprint.

  • Cite this