A fatal gastric perforation secondary to ulcerated metastasis in undiagnosed breast cancer: Pathological aspects and review of literature

Rosario Barranco, Giulio Fraternali Orcioni, Francesco Ventura

Research output: Contribution to journalReview article

Abstract

The authors describe a fatal case of gastric perforation secondary to an ulcerated metastasis in a woman with undiagnosed breast cancer. The 48-year-old woman, with no significant medical history, presented with weight loss, persistent dyspepsia and pain in the epigastric and mesogastric region. She was treated by her primary care physician with proton-pump inhibitors and antispasmodics. The following day she was found dead at her home. External examination showed a tumefaction in the lateral region of her left breast, near the axilla. Autopsy revealed 1000 ml of turbid, light-brown peritoneal fluid in the abdominal cavity and a perforated gastric wall. Histological examination of the breast mass showed an infiltrating, poorly-differentiated breast carcinoma. Microscopical analysis of the stomach wall revealed a perforated metastatic gastric ulcer. Immunohistochemistry was required to confirm the neoplastic involvement of the stomach due to metastatic breast cancer.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalMalaysian Journal of Pathology
Volume39
Issue number2
Publication statusPublished - Aug 1 2017

Keywords

  • Breast cancer
  • Fatal peritonitis
  • Gastric metastasis
  • Gastric perforation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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