A feasibility study using polychemotherapy (cisplatin + vindesine + dacarbazine) plus interferon-alpha or monochemotherapy with dacarbazine plus interferon-alpha in metastatic melanoma

E. Bajetta, M. Del Vecchio, M. Vitali, A. Martinetti, L. Ferrari, P. Queirolo, M. R. Sertoli, T. Cainelli, R. Cellerino, N. Cascinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and background: This trial evaluated the feasibility and tolerability of an immunochemotherapeutic approach that uses cisplatin, vindesine, and dacarbazine (DTIC), or only DTIC, in combination with interferon alpha-2a (IFN-α), in patients with metastatic melanoma, considering the significant toxicity of several different regimens used up to now. Methods: Between May 1995 and September 1997, 51 melanoma patients (50 of whom were assessable) entered a multicentric trial and were randomized to receive cisplatin (30 mg/m2 daily for 3 days) + vindesine (2.5 mg/m2 only day 1) + DTIC (250 mg/m2 daily for 3 consecutive days) + IFN-α (3 MIU im 3×/wk continuously) (CVD arm) versus DTIC (800 mg/m2 day 1) + IFN-α (3 MIU im 3×/wk continuously) (DTIC arm). The chemotherapy was recycled every 21 days. Patient reevaluation was performed every two cycles, and the treatment was continued in case of objective response or stabilization of disease. Results: We observed 3 complete responses, 2 partial responses and 5 stable diseases in the CVD arm, and 2 partial responses and 4 stabilizations of disease in the DTIC arm. Conclusions: We conclude that these chemotherapeutic regimens are well tolerated regimens with modest toxicity. Future trials will be conducted associating the CVD regimen with biological response modifiers (IFN, IL-2) in order to improve the results.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalTumori
Volume87
Issue number4
Publication statusPublished - 2001

Keywords

  • Chemotherapy
  • Immunotherapy
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research

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