Efficacia verso la parotite di tre diversi vaccini a tripla componente: Studio sul campo

Translated title of the contribution: A field study on vaccine efficacy against mumps of three MMR vaccines

F. Marolla, G. Baviera, [No Value] Cacciapuoti, V. Calia, R. Cannavo, A. Clemente, E. Coltura, S. Corbo, M. Corgiolu, M. L. Criscione, T. Gazzotti, L. Marolla, F. Melideo, L. Oliviero, P. Panizzi, L. Tebaldi, M. Traditi, S. Uccella, C. Vignuda, R. ZandA. E. Tozzi

Research output: Contribution to journalArticlepeer-review


The observation of many cases of mumps in vaccinated children during the 1995-96 period prompted a group of family paediatricians to perform a field evaluation on mumps vaccine efficacy of MMR vaccines. Three-thousands-fifty children in the age range 18 months-7 years and 6 months were enrolled during May and June 1996. Data on 2,099 of them (68.8%) who received one of the three most used MMR vaccine and 646 unvaccinated children (21.2%) were analysed. One-hundred-twenty-four cases of measles (8% in vaccinated children), and 457 cases of mumps (55% in vaccinated children) were reported during a period up to six years since 1990. Vaccine efficacy against measles was 100% for Pluserix®, 95% for Triviraten® (CI 90-98%), and 97% for Morupar® (CI 88-99%). Vaccine efficacy against mumps was 75% for Pluserix® (CI 65-83%), 23% for Triviraten® (CI 6-37%), and 73% for Morupar® (CI 59- 82%). These results confirm the recent observations that the Rubini strain (contained in Triviraten®) has a low efficacy when compared to the Urabe strain (contained in Pluserix® and Morupar®) in preventing mumps. These results also underline that a booster dose for mumps vaccine should be considered in the pre-adolescent age.

Translated title of the contributionA field study on vaccine efficacy against mumps of three MMR vaccines
Original languageItalian
Pages (from-to)466-472
Number of pages7
JournalRivista Italiana di Pediatria
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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