Efficacia verso la parotite di tre diversi vaccini a tripla componente: Studio sul campo

Translated title of the contribution: A field study on vaccine efficacy against mumps of three MMR vaccines

F. Marolla, G. Baviera, [No Value] Cacciapuoti, V. Calia, R. Cannavo, A. Clemente, E. Coltura, S. Corbo, M. Corgiolu, M. L. Criscione, T. Gazzotti, L. Marolla, F. Melideo, L. Oliviero, P. Panizzi, L. Tebaldi, M. Traditi, S. Uccella, C. Vignuda, R. ZandA. E. Tozzi

Research output: Contribution to journalArticle

Abstract

The observation of many cases of mumps in vaccinated children during the 1995-96 period prompted a group of family paediatricians to perform a field evaluation on mumps vaccine efficacy of MMR vaccines. Three-thousands-fifty children in the age range 18 months-7 years and 6 months were enrolled during May and June 1996. Data on 2,099 of them (68.8%) who received one of the three most used MMR vaccine and 646 unvaccinated children (21.2%) were analysed. One-hundred-twenty-four cases of measles (8% in vaccinated children), and 457 cases of mumps (55% in vaccinated children) were reported during a period up to six years since 1990. Vaccine efficacy against measles was 100% for Pluserix®, 95% for Triviraten® (CI 90-98%), and 97% for Morupar® (CI 88-99%). Vaccine efficacy against mumps was 75% for Pluserix® (CI 65-83%), 23% for Triviraten® (CI 6-37%), and 73% for Morupar® (CI 59- 82%). These results confirm the recent observations that the Rubini strain (contained in Triviraten®) has a low efficacy when compared to the Urabe strain (contained in Pluserix® and Morupar®) in preventing mumps. These results also underline that a booster dose for mumps vaccine should be considered in the pre-adolescent age.

Translated title of the contributionA field study on vaccine efficacy against mumps of three MMR vaccines
Original languageItalian
Pages (from-to)466-472
Number of pages7
JournalRivista Italiana di Pediatria
Volume24
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'A field study on vaccine efficacy against mumps of three MMR vaccines: Studio sul campo'. Together they form a unique fingerprint.

  • Cite this

    Marolla, F., Baviera, G., Cacciapuoti, N. V., Calia, V., Cannavo, R., Clemente, A., Coltura, E., Corbo, S., Corgiolu, M., Criscione, M. L., Gazzotti, T., Marolla, L., Melideo, F., Oliviero, L., Panizzi, P., Tebaldi, L., Traditi, M., Uccella, S., Vignuda, C., ... Tozzi, A. E. (1998). Efficacia verso la parotite di tre diversi vaccini a tripla componente: Studio sul campo. Rivista Italiana di Pediatria, 24(3), 466-472.