{A figure is presented}Comparison of the Interobserver Reproducibility With Different Histologic Criteria Used in Celiac Disease

Gino Roberto Corazza, Vincenzo Villanacci, Claudia Zambelli, Massimo Milione, Ombretta Luinetti, Carla Vindigni, Caterina Chioda, Luca Albarello, Daniela Bartolini, Francesco Donato

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Background & Aims: The Marsh-Oberhuber classification of duodenojejunal mucosal lesions is currently used for celiac disease. A more simplified classification, which is based on 3 villous morphologies (A, non-atrophic; B1, atrophic, villous-crypt ratio 25/100 enterocytes, has recently been proposed. The aim of the study was to asses the interobserver agreement between different pathologists in classifying celiac disease lesions according to both Marsh-Oberhuber and the new classification system. Methods: Sixty patients were selected for the study: 10 subjects without celiac disease, 13 celiac patients with normal villi but a pathologic increase in intraepithelial lymphocytes >25/100 and hyperplastic crypts, and 37 patients with celiac disease with villous atrophy. Sixty slides were sent to 6 pathologists, who were blinded to each other and were not given any clinical information. Each pathologist received the set of biopsy specimens on 2 separate occasions and had to evaluate them according to both grading systems in a random order. The kappa statistic was used to assess agreement between each pair of pathologists. Results: Overall, mean kappa values were 0.35 (fair) for the Marsh-Oberhuber classification versus 0.55 (moderate) for the new classification system. Conclusions: The new classification for duodenal pathology in celiac disease gives better interobserver agreement compared with the more cumbersome Marsh-Oberhuber classification and contributes to the validity of diagnosis in celiac disease.

Original languageEnglish
Pages (from-to)838-843
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume5
Issue number7
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Celiac Disease
Wetlands
Enterocytes
Equidae
Abdomen
Atrophy
Lymphocytes
Pathology
Biopsy
Pathologists

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

{A figure is presented}Comparison of the Interobserver Reproducibility With Different Histologic Criteria Used in Celiac Disease. / Corazza, Gino Roberto; Villanacci, Vincenzo; Zambelli, Claudia; Milione, Massimo; Luinetti, Ombretta; Vindigni, Carla; Chioda, Caterina; Albarello, Luca; Bartolini, Daniela; Donato, Francesco.

In: Clinical Gastroenterology and Hepatology, Vol. 5, No. 7, 07.2007, p. 838-843.

Research output: Contribution to journalArticle

Corazza, Gino Roberto ; Villanacci, Vincenzo ; Zambelli, Claudia ; Milione, Massimo ; Luinetti, Ombretta ; Vindigni, Carla ; Chioda, Caterina ; Albarello, Luca ; Bartolini, Daniela ; Donato, Francesco. / {A figure is presented}Comparison of the Interobserver Reproducibility With Different Histologic Criteria Used in Celiac Disease. In: Clinical Gastroenterology and Hepatology. 2007 ; Vol. 5, No. 7. pp. 838-843.
@article{c628ce2fcd8041fb956a06da755b0102,
title = "{A figure is presented}Comparison of the Interobserver Reproducibility With Different Histologic Criteria Used in Celiac Disease",
abstract = "Background & Aims: The Marsh-Oberhuber classification of duodenojejunal mucosal lesions is currently used for celiac disease. A more simplified classification, which is based on 3 villous morphologies (A, non-atrophic; B1, atrophic, villous-crypt ratio 25/100 enterocytes, has recently been proposed. The aim of the study was to asses the interobserver agreement between different pathologists in classifying celiac disease lesions according to both Marsh-Oberhuber and the new classification system. Methods: Sixty patients were selected for the study: 10 subjects without celiac disease, 13 celiac patients with normal villi but a pathologic increase in intraepithelial lymphocytes >25/100 and hyperplastic crypts, and 37 patients with celiac disease with villous atrophy. Sixty slides were sent to 6 pathologists, who were blinded to each other and were not given any clinical information. Each pathologist received the set of biopsy specimens on 2 separate occasions and had to evaluate them according to both grading systems in a random order. The kappa statistic was used to assess agreement between each pair of pathologists. Results: Overall, mean kappa values were 0.35 (fair) for the Marsh-Oberhuber classification versus 0.55 (moderate) for the new classification system. Conclusions: The new classification for duodenal pathology in celiac disease gives better interobserver agreement compared with the more cumbersome Marsh-Oberhuber classification and contributes to the validity of diagnosis in celiac disease.",
author = "Corazza, {Gino Roberto} and Vincenzo Villanacci and Claudia Zambelli and Massimo Milione and Ombretta Luinetti and Carla Vindigni and Caterina Chioda and Luca Albarello and Daniela Bartolini and Francesco Donato",
year = "2007",
month = "7",
doi = "10.1016/j.cgh.2007.03.019",
language = "English",
volume = "5",
pages = "838--843",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - {A figure is presented}Comparison of the Interobserver Reproducibility With Different Histologic Criteria Used in Celiac Disease

AU - Corazza, Gino Roberto

AU - Villanacci, Vincenzo

AU - Zambelli, Claudia

AU - Milione, Massimo

AU - Luinetti, Ombretta

AU - Vindigni, Carla

AU - Chioda, Caterina

AU - Albarello, Luca

AU - Bartolini, Daniela

AU - Donato, Francesco

PY - 2007/7

Y1 - 2007/7

N2 - Background & Aims: The Marsh-Oberhuber classification of duodenojejunal mucosal lesions is currently used for celiac disease. A more simplified classification, which is based on 3 villous morphologies (A, non-atrophic; B1, atrophic, villous-crypt ratio 25/100 enterocytes, has recently been proposed. The aim of the study was to asses the interobserver agreement between different pathologists in classifying celiac disease lesions according to both Marsh-Oberhuber and the new classification system. Methods: Sixty patients were selected for the study: 10 subjects without celiac disease, 13 celiac patients with normal villi but a pathologic increase in intraepithelial lymphocytes >25/100 and hyperplastic crypts, and 37 patients with celiac disease with villous atrophy. Sixty slides were sent to 6 pathologists, who were blinded to each other and were not given any clinical information. Each pathologist received the set of biopsy specimens on 2 separate occasions and had to evaluate them according to both grading systems in a random order. The kappa statistic was used to assess agreement between each pair of pathologists. Results: Overall, mean kappa values were 0.35 (fair) for the Marsh-Oberhuber classification versus 0.55 (moderate) for the new classification system. Conclusions: The new classification for duodenal pathology in celiac disease gives better interobserver agreement compared with the more cumbersome Marsh-Oberhuber classification and contributes to the validity of diagnosis in celiac disease.

AB - Background & Aims: The Marsh-Oberhuber classification of duodenojejunal mucosal lesions is currently used for celiac disease. A more simplified classification, which is based on 3 villous morphologies (A, non-atrophic; B1, atrophic, villous-crypt ratio 25/100 enterocytes, has recently been proposed. The aim of the study was to asses the interobserver agreement between different pathologists in classifying celiac disease lesions according to both Marsh-Oberhuber and the new classification system. Methods: Sixty patients were selected for the study: 10 subjects without celiac disease, 13 celiac patients with normal villi but a pathologic increase in intraepithelial lymphocytes >25/100 and hyperplastic crypts, and 37 patients with celiac disease with villous atrophy. Sixty slides were sent to 6 pathologists, who were blinded to each other and were not given any clinical information. Each pathologist received the set of biopsy specimens on 2 separate occasions and had to evaluate them according to both grading systems in a random order. The kappa statistic was used to assess agreement between each pair of pathologists. Results: Overall, mean kappa values were 0.35 (fair) for the Marsh-Oberhuber classification versus 0.55 (moderate) for the new classification system. Conclusions: The new classification for duodenal pathology in celiac disease gives better interobserver agreement compared with the more cumbersome Marsh-Oberhuber classification and contributes to the validity of diagnosis in celiac disease.

UR - http://www.scopus.com/inward/record.url?scp=34447094635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447094635&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2007.03.019

DO - 10.1016/j.cgh.2007.03.019

M3 - Article

C2 - 17544877

AN - SCOPUS:34447094635

VL - 5

SP - 838

EP - 843

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 7

ER -