A focused review of gender differences in antithrombotic therapy

Andrea Salzano, Pablo Demelo-Rodríguez, Alberto Maria Marra, Marco Proietti

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Background: The biological differences among male and female, based on distinctive expression of sex chromosomes, on varied gene-expression and on peculiar sexual hormones, lead to important differences in physiology and pathophysiology. Objective: The aim of this work was to briefly review the relationships among genderrelated differences and clinical implications in antithrombotic therapy, that could be related to sex-differences in platelet biology and coagulation reactions. Results: The major clinical setting in which antithrombotic drugs are involved for the treatment are atrial fibrillation, venous thromboembolisn, coronary artery disease and peripheral artery diseases. Considering that a consistent body of evidences suggests that, on one hand, human platelet activity may be influenced by sex and sex hormones and, on the other hand, estrogens are likely to play a crucial role on the transcriptional regulation of coagulation protein genes, the real impact of gender-related differences is still unclear. Moreover, women and men present different responses to antithrombotic drugs, reflecting genderspecific variances in pharmacokinetic profile, along with the physiological characteristics of each gender. Thus, the efficacy and adverse effects of antithrombotic drugs may vary according to gender. Conclusion: Several gender-related differences could be reported in haemostasis and thrombosis pathophysiological mechanisms. Moreover, several data documented relevant gender differences in antithrombotic management and clinical effectiveness. Further studies are still needed to completely elucidate these issues.

Original languageEnglish
Pages (from-to)2576-2588
Number of pages13
JournalCurrent Medicinal Chemistry
Volume24
Issue number24
DOIs
Publication statusPublished - Jan 1 2017

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Platelets
Coagulation
Blood Platelets
Pharmaceutical Preparations
Sex Chromosomes
Pharmacokinetics
Peripheral Arterial Disease
Physiology
Gonadal Steroid Hormones
Hemostasis
Gene expression
Human Activities
Sex Characteristics
Atrial Fibrillation
Coronary Artery Disease
Estrogens
Thrombosis
Therapeutics
Hormones
Gene Expression

Keywords

  • Antiplatelet drugs
  • Antithrombotic therapy
  • Coagulation system
  • Gender
  • NOACs
  • Oral anticoagulant therapy
  • Platelets activity
  • Vitamin K antagonist

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

A focused review of gender differences in antithrombotic therapy. / Salzano, Andrea; Demelo-Rodríguez, Pablo; Marra, Alberto Maria; Proietti, Marco.

In: Current Medicinal Chemistry, Vol. 24, No. 24, 01.01.2017, p. 2576-2588.

Research output: Contribution to journalReview article

Salzano, Andrea ; Demelo-Rodríguez, Pablo ; Marra, Alberto Maria ; Proietti, Marco. / A focused review of gender differences in antithrombotic therapy. In: Current Medicinal Chemistry. 2017 ; Vol. 24, No. 24. pp. 2576-2588.
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