A food pattern that is predictive of flavonol intake and risk of pancreatic cancer

Ute Nöthlings, Suzanne P. Murphy, Lynne R. Wilkens, Heiner Boeing, Matthias B. Schulze, H. Bas Bueno-de-Mesquita, Dominique S. Michaud, Andrew Roddam, Sabine Rohrmann, Anne Tjønneland, Francoise Clavel-Chapelon, Antonia Trichopoulou, Sabina Sieri, Laudina Rodriguez, Weimin Ye, Mazda Jenab, Laurence N. Kolonel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: In the Multiethnic Cohort (MEC) study, we showed inverse associations between flavonols and pancreatic cancer risk. Objective: We aimed to define a food pattern associated with intakes of quercetin, kaempferol, and myricetin; to examine the association of that pattern with pancreatic cancer risk; and to investigate the associations in an independent study. Design: Reduced rank regression was applied to dietary data for 183 513 participants in the MEC. A food group pattern was extracted and simplified and applied to dietary data of 424 978 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intake in both studies was assessed by using specially developed questionnaires. Multivariate Cox proportional hazards models were used to estimate relative risks for pancreatic cancer in the MEC (610 cases) and the EPIC (517 cases) studies. Results: The food group pattern consisted mainly of tea, fruit, cabbage, and wine. In the MEC, inverse associations with pancreatic cancer in smokers were observed for the food group pattern [relative risk: 0.59 (95% CI: 0.31, 1.12) when extreme quintiles were compared; P for trend = 0.03]. In the EPIC study, the simplified pattern was not associated with pancreatic cancer risk (P for trend = 0.78). Conclusions:Afood pattern associated with the intake of quercetin, kaempferol, and myricetin was associated with lower pancreatic cancer risk in smokers in a US-based population. However, failure to replicate the associations in an independent study weakens the conclusions and raises questions about the utility of food patterns for flavonols across populations.

Original languageEnglish
Pages (from-to)1653-1662
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume88
Issue number6
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

Pancreatic Neoplasms
Food
Flavonols
Quercetin
Neoplasms
Brassica
Tea
Wine
Proportional Hazards Models
Population
3-hydroxyflavone
Fruit
Cohort Studies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Nöthlings, U., Murphy, S. P., Wilkens, L. R., Boeing, H., Schulze, M. B., Bueno-de-Mesquita, H. B., ... Kolonel, L. N. (2008). A food pattern that is predictive of flavonol intake and risk of pancreatic cancer. American Journal of Clinical Nutrition, 88(6), 1653-1662. https://doi.org/10.3945/ajcn.2008.26398

A food pattern that is predictive of flavonol intake and risk of pancreatic cancer. / Nöthlings, Ute; Murphy, Suzanne P.; Wilkens, Lynne R.; Boeing, Heiner; Schulze, Matthias B.; Bueno-de-Mesquita, H. Bas; Michaud, Dominique S.; Roddam, Andrew; Rohrmann, Sabine; Tjønneland, Anne; Clavel-Chapelon, Francoise; Trichopoulou, Antonia; Sieri, Sabina; Rodriguez, Laudina; Ye, Weimin; Jenab, Mazda; Kolonel, Laurence N.

In: American Journal of Clinical Nutrition, Vol. 88, No. 6, 01.12.2008, p. 1653-1662.

Research output: Contribution to journalArticle

Nöthlings, U, Murphy, SP, Wilkens, LR, Boeing, H, Schulze, MB, Bueno-de-Mesquita, HB, Michaud, DS, Roddam, A, Rohrmann, S, Tjønneland, A, Clavel-Chapelon, F, Trichopoulou, A, Sieri, S, Rodriguez, L, Ye, W, Jenab, M & Kolonel, LN 2008, 'A food pattern that is predictive of flavonol intake and risk of pancreatic cancer', American Journal of Clinical Nutrition, vol. 88, no. 6, pp. 1653-1662. https://doi.org/10.3945/ajcn.2008.26398
Nöthlings U, Murphy SP, Wilkens LR, Boeing H, Schulze MB, Bueno-de-Mesquita HB et al. A food pattern that is predictive of flavonol intake and risk of pancreatic cancer. American Journal of Clinical Nutrition. 2008 Dec 1;88(6):1653-1662. https://doi.org/10.3945/ajcn.2008.26398
Nöthlings, Ute ; Murphy, Suzanne P. ; Wilkens, Lynne R. ; Boeing, Heiner ; Schulze, Matthias B. ; Bueno-de-Mesquita, H. Bas ; Michaud, Dominique S. ; Roddam, Andrew ; Rohrmann, Sabine ; Tjønneland, Anne ; Clavel-Chapelon, Francoise ; Trichopoulou, Antonia ; Sieri, Sabina ; Rodriguez, Laudina ; Ye, Weimin ; Jenab, Mazda ; Kolonel, Laurence N. / A food pattern that is predictive of flavonol intake and risk of pancreatic cancer. In: American Journal of Clinical Nutrition. 2008 ; Vol. 88, No. 6. pp. 1653-1662.
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AU - Michaud, Dominique S.

AU - Roddam, Andrew

AU - Rohrmann, Sabine

AU - Tjønneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Trichopoulou, Antonia

AU - Sieri, Sabina

AU - Rodriguez, Laudina

AU - Ye, Weimin

AU - Jenab, Mazda

AU - Kolonel, Laurence N.

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N2 - Background: In the Multiethnic Cohort (MEC) study, we showed inverse associations between flavonols and pancreatic cancer risk. Objective: We aimed to define a food pattern associated with intakes of quercetin, kaempferol, and myricetin; to examine the association of that pattern with pancreatic cancer risk; and to investigate the associations in an independent study. Design: Reduced rank regression was applied to dietary data for 183 513 participants in the MEC. A food group pattern was extracted and simplified and applied to dietary data of 424 978 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intake in both studies was assessed by using specially developed questionnaires. Multivariate Cox proportional hazards models were used to estimate relative risks for pancreatic cancer in the MEC (610 cases) and the EPIC (517 cases) studies. Results: The food group pattern consisted mainly of tea, fruit, cabbage, and wine. In the MEC, inverse associations with pancreatic cancer in smokers were observed for the food group pattern [relative risk: 0.59 (95% CI: 0.31, 1.12) when extreme quintiles were compared; P for trend = 0.03]. In the EPIC study, the simplified pattern was not associated with pancreatic cancer risk (P for trend = 0.78). Conclusions:Afood pattern associated with the intake of quercetin, kaempferol, and myricetin was associated with lower pancreatic cancer risk in smokers in a US-based population. However, failure to replicate the associations in an independent study weakens the conclusions and raises questions about the utility of food patterns for flavonols across populations.

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