TY - JOUR
T1 - A G-CSF functionalized PLLA scaffold for wound repair
T2 - An in vitro preliminary study.
AU - Spadaccio, Cristiano
AU - Rainer, Alberto
AU - De Porcellinis, Stefano
AU - Centola, Matteo
AU - De Marco, Federico
AU - Chello, Massimo
AU - Trombetta, Marcella
AU - Genovese, Jorge A.
PY - 2010
Y1 - 2010
N2 - Targeting wound repair, we developed an electrospun poly-L-lactide fibrous scaffold functionalized with G-CSF, a growth factor which is widely recognized as important in wound healing homeostasis. The scaffold was characterized in terms of morphology, mechanical properties and in vitro capacity to induce organization of co-cultures of murine fibroblasts and keratinocytes into a dermo-epidermal multilayered structure. Our findings are consistent with the promotion of a nonhostile environment, in which seeded cells could arrange themselves in an appropriate topographic distribution of elements at different levels of maturation up to a cornified epithelium on the top layer, resembling native skin.
AB - Targeting wound repair, we developed an electrospun poly-L-lactide fibrous scaffold functionalized with G-CSF, a growth factor which is widely recognized as important in wound healing homeostasis. The scaffold was characterized in terms of morphology, mechanical properties and in vitro capacity to induce organization of co-cultures of murine fibroblasts and keratinocytes into a dermo-epidermal multilayered structure. Our findings are consistent with the promotion of a nonhostile environment, in which seeded cells could arrange themselves in an appropriate topographic distribution of elements at different levels of maturation up to a cornified epithelium on the top layer, resembling native skin.
UR - http://www.scopus.com/inward/record.url?scp=84903855652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903855652&partnerID=8YFLogxK
M3 - Article
C2 - 21096315
SP - 843
EP - 846
JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
SN - 1557-170X
ER -