TY - JOUR
T1 - A GC/MS-MS versus GC/HRMS dioxin analysis comparison
T2 - Some critical considerations for low-level environmental samples
AU - Palmiotto, Marinella
AU - Colombo, Andrea
AU - Davoli, Enrico
PY - 2013
Y1 - 2013
N2 - Current European Union regulations permit the use of GC/MS-MS and bioassay techniques, for screening dioxins, only in feed and food samples. In this work, we present a critical comparison of the official GC/HRMS methods and GC/MS-MS approach for the determination of PCDDs and PCDFs congeners in environmental samples.Polychlorinated dibenzo- p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are a class of ubiquitous persistent organic pollutants, formed mainly during combustion processes, which have a high toxic potential. Many countries have now compiled inventories of dioxin sources to better understand and quantify the amounts of PCDD/Fs emitted. Official methods for PCDD and PCDF analyses are based on gas chromatography/high-resolution mass spectrometry (GC/HRMS) due to high sensitivity and selectivity. However, there are more and more evidences that it is possible to perform screening of these environmental pollutants using a GC/MS or a more specific tandem GC/MS-MS approach. GC coupled to triple quadrupole MS allows higher throughput, lower maintenance, and ultimately lower costs per analysis. Current European Union regulations permit the use of GC/MS-MS and bioassay techniques for screening dioxins only in feed and food samples. In this work, we present a critical comparison of the official GC/HRMS methods and GC/MS-MS approach for the determination of PCDDs and PCDFs congeners in environmental air and soil samples.
AB - Current European Union regulations permit the use of GC/MS-MS and bioassay techniques, for screening dioxins, only in feed and food samples. In this work, we present a critical comparison of the official GC/HRMS methods and GC/MS-MS approach for the determination of PCDDs and PCDFs congeners in environmental samples.Polychlorinated dibenzo- p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are a class of ubiquitous persistent organic pollutants, formed mainly during combustion processes, which have a high toxic potential. Many countries have now compiled inventories of dioxin sources to better understand and quantify the amounts of PCDD/Fs emitted. Official methods for PCDD and PCDF analyses are based on gas chromatography/high-resolution mass spectrometry (GC/HRMS) due to high sensitivity and selectivity. However, there are more and more evidences that it is possible to perform screening of these environmental pollutants using a GC/MS or a more specific tandem GC/MS-MS approach. GC coupled to triple quadrupole MS allows higher throughput, lower maintenance, and ultimately lower costs per analysis. Current European Union regulations permit the use of GC/MS-MS and bioassay techniques for screening dioxins only in feed and food samples. In this work, we present a critical comparison of the official GC/HRMS methods and GC/MS-MS approach for the determination of PCDDs and PCDFs congeners in environmental air and soil samples.
KW - GC/HRMS
KW - GC/MS-MS
KW - PCDDs
KW - PCDFs
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U2 - 10.1016/B978-0-444-62623-3.00019-8
DO - 10.1016/B978-0-444-62623-3.00019-8
M3 - Article
AN - SCOPUS:84884682898
VL - 61
SP - 455
EP - 469
JO - Comprehensive Analytical Chemistry
JF - Comprehensive Analytical Chemistry
SN - 0166-526X
ER -