A gender based analysis of predictors of all cause death after transcatheter aortic valve implantation

Federico Conrotto, Fabrizio D'Ascenzo, Stefano Salizzoni, Patrizia Presbitero, Pierfrancesco Agostoni, Corrado Tamburino, Giuseppe Tarantini, Francesco Bedogni, Freek Nijhoff, Valeria Gasparetto, Massimo Napodano, Giuseppe Ferrante, Marco Luciano Rossi, Pieter Stella, Nedy Brambilla, Marco Barbanti, Francesca Giordana, Costanza Grasso, Giuseppe Biondi Zoccai, Claudio MorettiMaurizio D'Amico, Mauro Rinaldi, Fiorenzo Gaita, Sebastiano Marra

Research output: Contribution to journalArticle

Abstract

The impact of gender-related pathophysiologic features of severe aortic stenosis on transcatheter aortic valve implantation (TAVI) outcomes remains to be determined, as does the consistency of predictors of mortality between the genders. All consecutive patients who underwent TAVI at 6 institutions were enrolled in this study and stratified according to gender. Midterm all-cause mortality was the primary end point, with events at 30 days and at midterm as secondary end points. All events were adjudicated according to Valve Academic Research Consortium definitions. Eight hundred thirty-six patients were enrolled, 464 (55.5%) of whom were female. At midterm follow-up (median 365 days, interquartile range 100 to 516) women had similar rates of all-cause mortality compared with men (18.1% vs 22.6%, p = 0.11) and similar incidence of myocardial infarction and cerebrovascular accident. Gender did not affect mortality also on multivariate analysis. Among clinical and procedural features, glomerular filtration rate 2 (hazard ratio [HR] 2.55, 95% confidence interval [CI] 1.36 to 4.79) and systolic pulmonary arterial pressure >50 mm Hg (HR 2.26, 95% CI 1.26 to 4.02) independently predicted mortality in women, while insulin-treated diabetes (HR 3.45, 95% CI 1.47 to 8.09), previous stroke (HR 3.42, 95% CI 1.43 to 8.18), and an ejection fraction

Original languageEnglish
Pages (from-to)1269-1274
Number of pages6
JournalThe American Journal of Cardiology
Volume114
Issue number8
DOIs
Publication statusPublished - Oct 15 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Conrotto, F., D'Ascenzo, F., Salizzoni, S., Presbitero, P., Agostoni, P., Tamburino, C., Tarantini, G., Bedogni, F., Nijhoff, F., Gasparetto, V., Napodano, M., Ferrante, G., Rossi, M. L., Stella, P., Brambilla, N., Barbanti, M., Giordana, F., Grasso, C., Zoccai, G. B., ... Marra, S. (2014). A gender based analysis of predictors of all cause death after transcatheter aortic valve implantation. The American Journal of Cardiology, 114(8), 1269-1274. https://doi.org/10.1016/j.amjcard.2014.07.053