A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

Massimiliano Bonafè, Fabiola Olivieri, Luca Cavallone, Simona Giovagnetti, Francesca Marchegiani, Maurizio Cardelli, Carlo Pieri, Maurizio Marra, Roberto Antonicelli, Rosmarie Lisa, Maria Rosaria Rizzo, Giuseppe Paolisso, Daniela Monti, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Current literature indicates that elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. In this paper, we studied the IL-6 promoter genetic variability at -174 C/G locus and its effect on IL-6 serum levels in a total of 700 people from 60 to 110 years of age, including 323 centenarians. We found that the proportion of homozygotes for the G allele at -174 locus decreases in centenarian males, but not in centenarian females. Moreover, we found that, only among males, homozygotes for the G allele at -174 locus have higher IL-6 serum levels in comparison with carriers of the C allele. On the whole, our data suggest that those individuals who are genetically predisposed to produce high levels of IL-6 during aging, i.e. -174 locus GG homozygous men, are disadvantaged for longevity.

Original languageEnglish
Pages (from-to)2357-2361
Number of pages5
JournalEuropean Journal of Immunology
Volume31
Issue number8
DOIs
Publication statusPublished - 2001

Keywords

  • Aging
  • Centenarians
  • IL-6
  • Polymorphism

ASJC Scopus subject areas

  • Immunology

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