A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: A EUSTAR prospective study

Muriel Elhai, Jérôme Avouac, Ulrich A. Walker, Marco Matucci-Cerinic, Gabriela Riemekasten, Paolo Airo, Eric Hachulla, Gabriele Valentini, Patricia Carreira, Franco Cozzi, Alexandra Balbir Gurman, Yolanda Braun-Moscovici, Nemanja Damjanov, Lidia P. Ananieva, Raffaella Scorza, Sergio A. Jimenez, Joanna Busquets, Mengtao Li, U. Müller-Ladner, André KahanOliver Distler, Yannick Allanore, Serena Guiducci, Alan Tyndall, Giovanni Lapadula, Florenzo Iannone, Radim Becvar, Stanislaw Sierakowsky, Otylia Kowal Bielecka, Maurizio Cutolo, Alberto Sulli, Giovanna Cuomo, Serena Vettori, Simona Rednic, Ileana Nicoara, Panayiotis G. Vlachoyiannopoulos, Carlomaurizio Montecucco, Roberto Caporali, Srdan Novak, Laszlo Czirjak, Cecilia Varjú, Carlo Chizzolini, Eugene J. Kucharz, Anna Kotulska, Magdalena Kopec-Medrek, Malgorzata Widuchowska, Blaz Rozman, Carmel Mallia, Bernard Coleiro, Armando Gabrielli, Dominique Farge, A. Hij, Roger Hesselstrand, Agneta Scheja, Frank A. Wollheim, Duska Martinovic, M. Govoni, Andrea Lo Monaco, Nicolas Hunzelmann, Raffaele Pellerito, Lisa Maria Bambara, Paola Caramaschi, Carol Black, Christopher Denton, Jörg Henes, Vera Ortiz Santamaria, Stefan Heitmann, Dorota Krasowska, Matthias Seidel, Mara Oleszowsky, Harald Burkhardt, Andrea Himsel, Maria João Salvador, Bojana Stamenkovic, Aleksandra Stankovic, Mohammed Tikly, Maya N. Starovoytova, Merete Engelhart, Gitte Strauss, H. Nielsen, Kirsten Damgaard, Gabriela Szucs, Antonio Zea Mendoza, Carlos de la Puente Buijdos, Walter A Sifuentes Giraldo, Øyvind Midtvedt, Torhild Garen, David Launay, G. Valesini, Valeria Riccieri, Ruxandra Maria Ionescu, Daniela Opris, Laura Groseanu, Fredrick M. Wigley, Carmen Marina Mihai, Roxana Sfrent Cornateanu, Razvan Ionitescu, Ana Maria Gherghe, Marilena Gorga, Rucsandra Dobrota, Mihai Bojinca, Georg Schett, Jörg H W Distler, Pier Luigi Meroni, Silvana Zeni, Luc Mouthon, F. De Keyser, Vanessa Smith, F. Cantatore, Ada Corrado, Susanne Ullman, Line Iversen, Maria Rosa Pozzi, Kilian Eyerich, Rüdiger Hein, Elisabeth Knott, Jacek Szechinski, Piotr Wiland, Magdalena Szmyrka-Kaczmarek, Renata Sokolik, Ewa Morgiel, Brigitte Krummel-Lorenz, Petra Saar, Martin Aringer, Claudia Günther, Branimir Anic, Marko Baresic, Miroslav Mayer, Sebastião Cezar Radominski, Carolina De Souza Müller, Valderílio Feijó Azevedo, Svetlana Agachi, Liliana Groppa, Lealea Chiaburu, Eugen Russu, Thierry Zenone, Simon Stebbings, John Highton, Lisa Stamp, Peter Chapman, Murray Baron, John O'Donnell, Kamal Solanki, Alan Doube, Douglas J. Veale, Marie O'Rourke, Esthela Loyo, Edoardo Rosato, Simonetta Pisarri, Cristina Mihaela Tanaseanu, Monica Popescu, Alina Dumitrascu, Isabela Tiglea, Rodica Chirieac, Codrina Michaela Ancuta, Daniel E. Furst, Suzanne Kafaja, Paloma García De La Peña Lefebvre, Silvia Rodriguez Rubio, Marta Valero Exposito, Jean Sibilia, Emmanuel Chatelus, Jacques Eric Gottenberg, Hélène Chifflot, Ira Litinsky, Algirdas Venalis, Irena Butrimiene, Paulius Venalis, Rita Rugiene, Diana Karpec, Eduardo Kerzberg, Fabiana Montoya, Vanesa Cosentino

Research output: Contribution to journalArticle

Abstract

Objectives. In agreement with other autoimmune diseases, systemic sclerosis (SSc) is associated with a strong sex bias. However, unlike lupus, the effects of sex on disease phenotype and prognosis are poorly known. Therefore, we aimed to determine sex effects on outcomes. Method. We performed a prospective observational study using the latest 2013 data extract from the EULAR scleroderma trials and research (EUSTAR) cohort. We looked at (i) sex influence on disease characteristics at baseline and (ii) then focused on patients with at least 2 years of follow-up to estimate the effects of sex on disease progression and survival. Results. 9182 patients with SSc were available (1321 men) for the baseline analyses. In multivariate analysis, male sex was independently associated with a higher risk of diffuse cutaneous subtype (OR: 1.68, (1.45 to 1.94); p

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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    Elhai, M., Avouac, J., Walker, U. A., Matucci-Cerinic, M., Riemekasten, G., Airo, P., Hachulla, E., Valentini, G., Carreira, P., Cozzi, F., Gurman, A. B., Braun-Moscovici, Y., Damjanov, N., Ananieva, L. P., Scorza, R., Jimenez, S. A., Busquets, J., Li, M., Müller-Ladner, U., ... Cosentino, V. (2016). A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: A EUSTAR prospective study. Annals of the Rheumatic Diseases, 75(1), 163-169. https://doi.org/10.1136/annrheumdis-2014-206386