TY - JOUR
T1 - A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer?
AU - Palli, Domenico
AU - Masala, Giovanna
AU - Mariani-Costantini, Renato
AU - Zanna, Ines
AU - Saieva, Calogero
AU - Sera, Francesco
AU - Decarli, Adriano
AU - Ottini, Laura
PY - 2004/11
Y1 - 2004/11
N2 - The association of male breast cancer (MBC) with a positive breast cancer (BC) family history and with BRCA1/2 germ-line mutations points to a genetic component; a relationship with occupation has also been reported. Recently, we identified pathogenetic BRCA1/2 mutations in a population-based series of Italian MBC patients: here in, we investigated interactions between a carrier status for BRCA1/2 mutations and occupation using a case-case design and estimating case-only odds ratios (CORs). Truck-driving was the most frequent occupation (3/4 BRCA-related cases and 2/19 unrelated cases). An interaction between carrier status and working as a truck-driver emerged, when we classified MBC cases as "ever/never-held" this job title (COR 25.5; 95% Confidence Limits (CL): 1.1-1,412.5) or according to truck-driving as the "longest-held" work (COR 54.0; 95% CL: 1.6-2,997.5). The possible modifying effect on MBC risk in subjects carrying BRCA1/2 germ-line mutations of an occupation characterised by exposure to chemicals such as polycyclic aromatic hydrocarbons (PAH) that are capable of inducing DNA damage, may provide clues to the role of environmental exposures in modifying BC risk in mutation carriers in both genders.
AB - The association of male breast cancer (MBC) with a positive breast cancer (BC) family history and with BRCA1/2 germ-line mutations points to a genetic component; a relationship with occupation has also been reported. Recently, we identified pathogenetic BRCA1/2 mutations in a population-based series of Italian MBC patients: here in, we investigated interactions between a carrier status for BRCA1/2 mutations and occupation using a case-case design and estimating case-only odds ratios (CORs). Truck-driving was the most frequent occupation (3/4 BRCA-related cases and 2/19 unrelated cases). An interaction between carrier status and working as a truck-driver emerged, when we classified MBC cases as "ever/never-held" this job title (COR 25.5; 95% Confidence Limits (CL): 1.1-1,412.5) or according to truck-driving as the "longest-held" work (COR 54.0; 95% CL: 1.6-2,997.5). The possible modifying effect on MBC risk in subjects carrying BRCA1/2 germ-line mutations of an occupation characterised by exposure to chemicals such as polycyclic aromatic hydrocarbons (PAH) that are capable of inducing DNA damage, may provide clues to the role of environmental exposures in modifying BC risk in mutation carriers in both genders.
KW - BRCA1
KW - BRCA2
KW - Gene-environment interaction
KW - Male breast cancer
KW - Occupation
KW - Polycyclic aromatic hydrocarbons
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U2 - 10.1016/j.ejca.2004.07.012
DO - 10.1016/j.ejca.2004.07.012
M3 - Article
C2 - 15519522
AN - SCOPUS:7044273939
VL - 40
SP - 2474
EP - 2479
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 16
ER -