A gene family for acidic ribosomal proteins in Schizosaccharomyces pombe: Two essential and two nonessential genes

M. Beltrame, M. E. Bianchi

Research output: Contribution to journalArticle

Abstract

We have cloned the genes for small acidic ribosomal proteins ns) of the fission yeast Schizosaccharomyces pombe. S. pombe contains four transcribed genes for small A-proteins per haploid genome, as is the case for Saccharomyces cerevisiae. In contrast, multicellular eucaryotes contain two transcribed genes per haploid genome. The four proteins of S. pombe, besides sharing a high overall similarity, form two couples of nearly identical sequences. Their corresponding genes have a very conserved structure and are transcribed to a similar level. Surprisingly, of each couple of genes coding for nearly identical proteins, one is essential for cell growth, whereas the other is not. We suggest that the unequal importance of the four small A-proteins for cell survival is related to their physical organization in 60S ribosomal subunits.

Original languageEnglish
Pages (from-to)2341-2348
Number of pages8
JournalMolecular and Cellular Biology
Volume10
Issue number5
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

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