A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1

M. Mangino, D. C. Salpietro, D. Zuccarello, S. Gangemi, L. Rigoli, M. V. Merlino, S. Briuglia, G. Bisignano, R. Mingarelli, B. Dallapiccola

Research output: Contribution to journalArticle

Abstract

Chronic mucocutaneous candidiases (CMC) are a group of rare disorders where an altered immune response against Candida leads to persistent and/or recurrent infections of the skin, nails, and mucous membranes. We analysed a five-generation Italian family with an isolated form of CMC, affecting nails only, in the presence of low serum concentration of intercellular adhesion molecule I (ICAM-1). We excluded linkage to candidate regions on chromosomes 2p (CMC with thyroid disease), 21q22.3 (APECED), and 19q13 (ICAM-1). We then carried out a enome-wide scan and assigned the CMC locus to a 19cM pericentromeric region on chromosome 11.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalEuropean Journal of Human Genetics
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Chronic Mucocutaneous Candidiasis
Candidiasis
Nails
Chromosomes
Intercellular Adhesion Molecule-1
Genes
Autoimmune Polyendocrinopathies
Chromosomes, Human, Pair 11
Thyroid Diseases
Immune System Diseases
Cell Adhesion Molecules
Candida
Mucous Membrane
Skin
Infection
Serum

Keywords

  • Candida
  • Chromosome 11
  • CMC
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1. / Mangino, M.; Salpietro, D. C.; Zuccarello, D.; Gangemi, S.; Rigoli, L.; Merlino, M. V.; Briuglia, S.; Bisignano, G.; Mingarelli, R.; Dallapiccola, B.

In: European Journal of Human Genetics, Vol. 11, No. 6, 01.06.2003, p. 433-436.

Research output: Contribution to journalArticle

Mangino, M, Salpietro, DC, Zuccarello, D, Gangemi, S, Rigoli, L, Merlino, MV, Briuglia, S, Bisignano, G, Mingarelli, R & Dallapiccola, B 2003, 'A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1', European Journal of Human Genetics, vol. 11, no. 6, pp. 433-436. https://doi.org/10.1038/sj.ejhg.5200985
Mangino M, Salpietro DC, Zuccarello D, Gangemi S, Rigoli L, Merlino MV et al. A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1. European Journal of Human Genetics. 2003 Jun 1;11(6):433-436. https://doi.org/10.1038/sj.ejhg.5200985
Mangino, M. ; Salpietro, D. C. ; Zuccarello, D. ; Gangemi, S. ; Rigoli, L. ; Merlino, M. V. ; Briuglia, S. ; Bisignano, G. ; Mingarelli, R. ; Dallapiccola, B. / A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1. In: European Journal of Human Genetics. 2003 ; Vol. 11, No. 6. pp. 433-436.
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