A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1

M. Mangino, D. C. Salpietro, D. Zuccarello, S. Gangemi, L. Rigoli, M. V. Merlino, S. Briuglia, G. Bisignano, R. Mingarelli, B. Dallapiccola

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic mucocutaneous candidiases (CMC) are a group of rare disorders where an altered immune response against Candida leads to persistent and/or recurrent infections of the skin, nails, and mucous membranes. We analysed a five-generation Italian family with an isolated form of CMC, affecting nails only, in the presence of low serum concentration of intercellular adhesion molecule I (ICAM-1). We excluded linkage to candidate regions on chromosomes 2p (CMC with thyroid disease), 21q22.3 (APECED), and 19q13 (ICAM-1). We then carried out a enome-wide scan and assigned the CMC locus to a 19cM pericentromeric region on chromosome 11.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalEuropean Journal of Human Genetics
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Candida
  • Chromosome 11
  • CMC
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)

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