A genetic analysis of stereotypy in the mouse: Dopaminergic plasticity following chronic stress

Simona Cabib, Stefano Puglisi-Allegra, Alberto Oliverio

Research output: Contribution to journalArticle

Abstract

After repeated stressful experiences, DBA/2 (DBA) mice showed an increase in apomorphine-induced climbing while C57BL/6 (C57) mice showed a clear-cut decrease of this behavior. Genetic analysis involving F1 and F2 hybrids and the backcross populations (F1 × C57; F1 × DBA) indicated complete dominance of the C57 genotype and a significant genotype × environment interaction. These findings are discussed in terms of dopaminergic plasticity and of the heuristic value of this animal model in relation to disturbed behaviors triggered by stressful experiences.

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalBehavioral and Neural Biology
Volume44
Issue number2
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Physiology

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