A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism

Maurizio Cardelli, Luca Cavallone, Francesca Marchegiani, Fabiola Oliveri, Serena Dato, Alberto Montesanto, Francesco Lescai, Rosamaria Lisa, Giovanna De Benedictis, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

The (A/G)-308 polymorphism of the tumor necrosis factor α gene (TNF) is associated with age-related diseases, but its influence on longevity is controversial. We genotyped for this polymorphism 747 Italian volunteers (401 women and 346 men, age 19-110 years). By applying a genetic-demographic (GD) approach we found that, in men, the survival function of allele A carriers is lower than that of noncarriers at all the ages (p = .044). After defining (by exploiting again demographic information) three age classes, we found that the frequency of men carrying the A allele decreases with age (p = .019), thus confirming the GD analysis results. The same analyses gave negative results in women. Therefore, allele A has a detrimental effect on life expectancy, and this effect is specific to men. A haplotype analysis carried out in men by screening the TNFa, TNFc, and TNFe microsatellite polymorphisms (spanning about 20 kb) confirmed the association of the TNF region with life expectancy.

Original languageEnglish
Pages (from-to)454-460
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume63
Issue number5
Publication statusPublished - May 2008

Keywords

  • Genetic-demographic approach
  • Longevity
  • TNF microsatellites
  • TNF(A/G)-308 polymorphism

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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